连续血液净化对多发伤并发MODS患者血浆B型利钠肽的影响  

Effect of continuous blood purification on plasma B-type natriuretic peptide of multiple trauma patients with multiple organ dysfunction syndrome

作　　者：崔勇[1] 潘鹏飞[1] 张可祥[1] 崔吉文[1] 

机构地区：[1]重庆三峡中心医院重症医学科,重庆万州404100

出　　处：《西部医学》2012年第2期252-253,256,共3页Medical Journal of West China

摘　　要：目的探讨连续血液净化(CBP)对多发伤并发多器官功能障碍综合征(MODS)患者血浆B型利钠肽(BNP)的影响。方法 17例多发伤并发MODS患者行连续性静脉-静脉血液滤过(CVVH),于治疗前后分别抽取静脉血,采用化学发光法测定血浆BNP的水平,并观察治疗前后K+、BUN、Scr、C反应蛋白以及动脉血气的变化。结果 17例患者CBP后血浆BNP水平下降(P<0.05),BUN、Scr、K+及C反应蛋白均下降(P<0.05或P<0.01),氧合指数上升(P<0.05)。结论多发伤并发MODS患者血浆BNP水平升高。CBP有助于降低血浆BNP水平,并可改善血液生化指标。Objective To investigate the effect of continuous blood purification（CBP） on plasma B-type natriuretic peptide（BNP） of multiple trauma patients with multiple organ dysfunction syndrome（MODS）.Methods Seventeen multiple trauma patients with MODS were received continuous veno-venous hemofiltration（CVVH）.The plasma BNP was measured by chemiluminescent measurement before and after CBP.The levels of K＋,BUN,Scr,C-reactive protein and arterial blood gas were measured too.Results The pasma concentration of BNP decreased after CBP（P0.05）.The levels of BUN,Scr,K＋ and C-reactive protein all decreased after CBP（P0.05 or P0.01）.PO2/FiO2 increased after CBP（P0.05）.Conclusion The plasma concentration of BNP increase in multiple trauma patients with MODS.CBP is useful for decreasing BNP in plasma,and improve the blood biochemical indicators including K＋,BUN,Scr and C-reactive protein.

关 键 词：连续血液净化 B型利钠肽 多发伤 多器官功能障碍综合征 

分 类 号：R641[医药卫生—外科学]