原发性高血压患者外周血内吗啡肽-1水平及其与年龄相关性的实验研究  

Experimental Study on the Level of Peripheral Endomorphin-1 in Primary Hypertension Patients and Its Association with Age

作　　者：白三省[1] 陈文生[1] 刘雅[1] 张金洲[1] 赵堃[1] 

机构地区：[1]第四军医大学西京医院心血管外科,陕西西安710032

出　　处：《临床医学工程》2012年第2期193-194,198,共3页Clinical Medicine & Engineering

摘　　要：目的探讨原发性高血压患者外周血内吗啡肽-1水平及其与年龄的相关性。方法随机选取36例原发性高血压患者和32名健康志愿者,用放射免疫分析法检测外周血内吗啡肽-1(endomorphin-1,EM-1)水平。结果原发性高血压患者外周血EM-1水平较正常志愿者明显下降(838±91pg/mlvs1157±84pg/ml,P<0.01),多元回归分析发现年龄是原发性高血压患者外周血EM-1水平的相关因子(P<0.05)。结论原发性高血压患者外周血EM-1水平较正常志愿者为低,且与年龄有相关性。Objective To study the endomorphin （EM-1） level in the peripheral blood in primary hypertension patients and its association with age. Methods Thirty-six primary hypertension patients and 32 healthy volunteers were selected randomly and their blood samples were drawn in heparinized tubes before breakfast. Plasma concentrations of EM-1 were measured by radioimmunoassay （RIA）. Results EM-1 levels were significantly lower in primary hypertension patients （838 ± 91 pg/ml vs 1 157 ± 84 pg/ml, P〈0.01） than in the healthy volunteers. The multiple correlation analysis showed significant changes （P 〈0.05） between the plasma EM-1 concentration in primary hypertension patients and their age. Conclusion Peripheral EM-1 level is suppressed in primary hypertension patients, which is related to age.

关 键 词：原发性高血压 内吗啡肽-1 放射免疫分析 

分 类 号：R544.1[医药卫生—心血管疾病]