温阳强心方对慢性充血性心力衰竭家兔细胞因子的影响  

Effects of Wenyang Qiangxin Decoction on Cytokines of Chronic Congestive Heart Failure Rabbits

作　　者：唐燕萍[1] 卢青[2] 谢海波[2] 刘越美[2] 蔡虎志[1] 陈新宇[2] 

机构地区：[1]湖南中医药大学,湖南长沙410007 [2]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《中国中医药信息杂志》2012年第2期35-36,40,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：湖南省教育厅科学研究重点项目(09A070)

摘　　要：目的探讨温阳强心方对家兔慢性充血性心力衰竭(CHF)模型细胞因子的影响。方法将50只家兔随机抽取10只为正常组,其余40只予以阿霉素静脉注射建立CHF模型。造模结束后行心脏彩超检查,根据心功能分层再随机分为4组:CHF模型组、卡托普利组、轻剂温阳强心方组及重剂温阳强心方组。卡托普利组予卡托普利悬液,轻剂温阳强心方组、重剂温阳强心方组分别予以不同剂量温阳强心方煎液灌胃,正常组和模型组予以等量的蒸馏水灌胃,每日1次,连续4周。实验结束时比较各组家兔肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)、内皮素-1(ET-1)的变化。结果温阳强心方能降低CHF家兔TNF-α、ET-1,升高IL-10,且重剂量组疗效优于轻剂量组。结论温阳强心方能调节阿霉素所致家兔CHF模型细胞因子网络系统,且重剂量组疗效优于轻剂量组。Objective To explore the effect of Wenyang Qiangxin decoction on cytokines of the rabbit model with chronic congestive heart failure（CHF）.Methods Fifty rabbits were randomly selected 10 as control group,and 40 were given adriamycin by intravenous injection to make heart failure model.The model rabbits were assigned randomly into four groups by the heart functions which were evaluated with echocardiography after modeling：model group,the captopril group,the low dose Wenyang Qiangxin decoction group and the high dose Wenyang Qiangxin decoction group.The treatment group was given captopril suspension,low dose Wenyang Qiangxin decoction,high dose Wenyang Qiangxin decoction respectively,and normal control group and the model group were given the same amount of distilled water once a day for 4 weeks.Tumor necrosis factor（TNF-α）,interleukin-10（IL-10） and endothelin-1（ET-1） were measured and compared at the end of the experiment.Results Wenyang Qiangxin decoction could reduce TNF-α,ET-1 and increase IL-10 of heart failure rabbits,and the high dose group was superior to the low dose group.Conclusions Wenyang Qiangxin decoction can regulate the cytokine network,and the high dose group was superior to the low dose group.

关 键 词：温阳强心方 慢性充血性心力衰竭 细胞因子 兔 

分 类 号：R285.5[医药卫生—中药学]