川芎嗪对肾间质纤维化大鼠中MMP-9、TIMP-1表达的影响  

Effects of Ligustrazine on Expression of MMP-9 and TIMP-1 in Rats with Renal Iinterstitial Fibrosis

作　　者：李健芝[1] 庾江东 刘玉明 胡丽[1] 刘丽君 周秀田[3] 莫文娟[1] 

机构地区：[1]南华大学护理学院,湖南省衡阳市421001 [2]湖南省衡阳市中心医院 [3]南华大学医学院病理教研室

出　　处：《医学理论与实践》2012年第3期249-251,共3页The Journal of Medical Theory and Practice

基　　金：湖南省教育厅课题(10C1159)

摘　　要：目的:观察川芎嗪对肾间质纤维化大鼠MMP-9、TIMP-1的影响并探讨其可能机制。方法:将32只雌性SD大鼠,随机分为4组,Shan组、模型组、川芎嗪治疗组、缬沙坦治疗组,并测定术后第14天MMP-9、TIMP-1的表达情况。结果:模型组肾小管间质区域以及肾小管上皮细胞MMP-9、TIMP-1的表达明显增强,川芎嗪治疗组与缬沙坦治疗组都能下调MMP-9、TIMP-1的表达,但两组间无显著差异。结论:川芎嗪通过下调MMP-9、TIMP-1表达,进而减缓肾纤维化的病程进展。Objective：To investigate the effects of Ligustrazine on renal interstitial fibrosis and its mechanism.Methods：Tirty-two female SD rats were divided into a sham-operated group,a UUO model group,a valsartan treated group and a Ligustrazine treated group.All rats were sacrificed 14 days after UUO.The expression of MMP-9 and TIMP-1 were detected.Results：The expression and distribution of MMP-9 and TIMP-1 were strong in UUO model group.Valsartan and Ligustrazine could decrease the expressions of MMP-9 and TIMP-1.There was no significant difference between valsartan group and Ligustrazine group.Conclusion：Ligustrazine could rilieve the renal intersitial fibrosis by decreasing MMP-9 and TIMP-1.

关 键 词：MMP-9 TIMP-1 肾间质纤维化 川芎嗪 缬沙坦 

分 类 号：R329.3[医药卫生—人体解剖和组织胚胎学]