HLA-DRB1 rs9269186,rs3135388 SNPs和环境因素与老年原发性高血压左室重构的关联性  

The correlation of left ventricular remodeling with HLA-DRB1 rs9269186,rs3135388 SNPs in elderly essential hypertension

作　　者：蔡丽伟[1] 孙艳伏[1] 王桂茹[1] 李波[2] 姜晶[1] 张洪[1] 陈红[1] 丁艳华[1] 

机构地区：[1]吉林大学白求恩第一临床医院,吉林长春130021 [2]吉林大学公共卫生学院

出　　处：《中国老年学杂志》2012年第4期667-672,共6页Chinese Journal of Gerontology

基　　金：国家自然科学基金面上项目(No.30872174)

摘　　要：目的探讨老年原发性高血压伴左室肥厚(EH-LVH)和左室扩大(EH-LVD)的相关危险因素。方法采用PCR-LDR技术对HLA-DRB1 rs9269186、rs3135388位点进行基因分型,通过二维超声和M型超声检查有无LVH和LVD。结果 rs9269186、rs3135388基因型及等位基因频率在EH伴有LVH组、LVD组或LVM/h组与对照组间差异均无统计学意义(P>0.05)。腰围(WL)、腹围(AC)在EH-LVD+组高于EH-LVD-组(P<0.05);体重指数(BMI)、WL、AC随LVM/h比值增高呈上升趋势,存在统计学意义(P<0.001),经多元素Logistic回归分析后BMI及AC仍与LVM/h相关联〔OR依次为2.417(95%CI:1.873～4.294),2.936(95%CI:1.113～7.747)〕。结论 BMI、AC可能是老年人EH左室重构的危险因素。HLA-DRB1 rs9269186,rs3135388单核甘酸多态性与老年EH左室重构无关。Objective To investigate the related risk factors of left ventricular hypertrophy（LVH） and left ventricular dilation（LVD） in elderly essential hypertension（EH）.Methods HLA-DRB1 single nucleotide polymorphisms（SNP,rs9269186 and rs3135388） were determined in 148 EH elderly subjects of Chinese Han population.Two SNPs were genotyped by multiplex polymerase chain reaction-ligase detection reaction.LVH and LVD were determined by the measurements of echocardiogram.Results There was no significant difference in genotype or allele frequencies of rs9269186 and rs3135388 between LVD,LVH,LVM/h groups and control groups（P〈0.05）.The levels of waistline（WL） and abdomen circumference（AC） in EH-LVD＋ group were significantly higher than those in EH-LVH-group（P〈0.05）.There was no difference of Clinical information and SNP between EH-LVH＋ group and EH-LVH-group.The levels of body mass index（BMI）,WL,AC were statistically increased with the increasing of ratio of LVM/h（P〈0.001）.Multivariate logistic regression analysis showed the relationship between BMI,AC and LVM/h（OR=2.417（95%CI：1.873～4.294）,2.936（95%CI：1.113～7.747））.Conclusions BMI and AC may be risk factors of EH related left ventricular remodeling in elderly patients.HLA-DRB1 rs9269186,rs3135388 may have no relationship with left ventricular remodeling.

关 键 词：老年原发性高血压 左室重构 人类白细胞抗原 单核苷酸多态性 相关因素 

分 类 号：R544.1[医药卫生—心血管疾病]