N-乙酰半胱氨酸治疗老年吸入性肺炎的疗效观察  

Clinical reseach on N-acetylcysteine in the treatment of elderly patients with aspiration pneumonia

作　　者：王中伟 冯晓玲 雷华[2] 

机构地区：[1]湖北省荣军医院老年病科,湖北武汉430079 [2]武汉市医疗救治中心武昌分院,湖北武汉430070

出　　处：《临床肺科杂志》2012年第3期408-409,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的观察N-乙酰半胱氨酸治疗老年吸入性肺炎疗效和安全性。方法将68例老年吸入性肺炎的患者随机分为治疗组和对照组,两组均给予常规治疗,治疗组加用N-乙酰半胱氨酸,然后比较两组血氧饱和度恢复时间、呼吸困难改善时间、吸痰次数、病灶吸收显效时间及平均住院天数等方面的差异。结果治疗结束时,两组血氧饱和度恢复时间、呼吸困难改善时间、吸痰次数、病灶吸收显效时间及平均住院天数等方面差异有显著性(P<0.01),且安全性较高。结论应用N-乙酰半胱氨酸治疗老年吸入性肺炎能明显改善患者的临床症状,缩短疗程,改善预后,无明显副反应。Objective To observe the efficacy and safety of tylcysteine in treatment of dderly aspiration pneumonia. Methods 68 elderly patients with aspiration pneumonia were randomly divided into treatment group and control group, who were given conventional treatment, while the treatment group plus NAC, and then the blood oxygen saturation recovery time, dyspnea improvement time, times of aspiration of sputum, foci absorption time and the average hospital stay time were compared between the two groups. Results The blood oxygen saturation recovery time, dyspnea improvement time, times of aspiration of sputum, foci absorption time and the average hospital stay time significantly improved in the treatment group compared with the control group, with significant differences（ P 〈 0.01 ）, moreo- ver, N-acetylcysteine in the treatment of elderly patients with aspiration pneumonia had higher security. Conclusion The inhalation of ace- tylcysteine in treatment of elderly patients with pneumonia can significantly improve the clinical symptoms, shorten the course of treatment, improve outcomes without significant side effects.

关 键 词：N-乙酰半胱氨酸 老年吸入性肺炎 

分 类 号：R563.1[医药卫生—呼吸系统]