重症监护病房铜绿假单胞菌感染的危险因素和耐药性分析  

Risk factors and drug-resistance of Pseudomonas aeruginosa infection in intensive care unit

作　　者：袁慧峰[1] 张琳[1] 赵红星[1] 许友松[1] 

机构地区：[1]合肥市第一人民医院重症医学科,安徽合肥230000

出　　处：《临床肺科杂志》2012年第3期437-438,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨医院重症监护病房(ICU)铜绿假单胞菌感染的危险因素和耐药性。方法对2009年9月至2011年9月入住ICU发生院内感染的198例患者临床资料进行统计分析。结果 198例院内感染病例中有53例为铜绿假单胞菌感染。多因素Logistic回归分析显示:机械通气(OR=3.365,95%CI 1.408-8.043)、深静脉置管(OR=3.591,95%CI 1.666-7.739)、慢性阻塞性肺疾病(COPD)(OR=5.728,95%CI 2.643-12.424)是铜绿假单胞菌感染的独立高危因素。药敏结果显示对亚胺培安耐药率最低,为22.0%。结论铜绿假单胞菌是ICU常见的致病菌,且多具有多重耐药性。Objective To investigate risk factors and drug - resistance of Pseudomonas aeruginosa infection in intensive care unit （ ICU）, and provide reference for clinical prevention and treatment. Methods A retrospective analysis of clinical data of 198 patients with nosocomial infection in ICU from September 2009 to September 2011 was done. Results Pseudomonas aeruginosa infection was 53 pa- tients in 198 patients with nosocomial infection. Logistic regression analysis revealed that mechanical ventilation （ OR = 3. 365,95% CI 1. 408 -8. 043） ,central venous cstheterization （OR =3. 591,95% CI 1. 666 -7. 739） ,COPD（OR =5. 728,95% CI 2. 643 - 12. 424） were independent risk factors of Pseudomonas aeruginosa infection. The resistance rate of Imipenem was the lowest （ 17% ）. Conclusion Pseudomonas aeruginosa is common pathogen in ICU, and it is usually muhidaug-resistance. The rational use of antibiotics and aseptic technique of invasive catheterization are important for prevention of Pseudomonas aeruginosa infection.

关 键 词：铜绿假单胞菌 耐药性 危险因素 

分 类 号：R446.5[医药卫生—诊断学]