艾滋病合并结核病患者抗结核治疗中肝损伤情况调查  

Clinical analysis of hepatotoxicityrelated to anti-tuberculosison in AIDS/TB patients

作　　者：吴念宁[1] 黄绍标[1] 陈万[1] 彭智鹏[1] 彭认平[1] 

机构地区：[1]南宁市第四人民医院,广西南宁530023

出　　处：《临床肺科杂志》2012年第3期461-462,共2页Journal of Clinical Pulmonary Medicine

基　　金：广西壮族自治区卫生厅项目(编号:Z20110097)

摘　　要：目的了解艾滋病合并结核病(HIV/TB)患者在标准化抗结核治疗中肝损伤的发生情况及对预后的影响。方法对361例HIV/TB患者在抗结核治疗最初2月内(强化期)肝损伤发生率、程度、预后情况进行总结,并随机抽取382例抗HIV阴性结核病患者做对照。结果 HIV/TB组肝损伤总发生率为40.2%,严重肝损伤发生率为10.8%,因肝损伤更改抗结核方案为14.4%,治疗失败率为7.8%;HIV阴性组肝损伤总发生率为21.7%、严重肝损伤率为4.5%、更改抗结核方案者为5.2%、治疗失败率为0.8%,两组比较有统计学意义。结论 AIDS/TB患者抗结核治疗中易发生肝损伤,严重肝损伤患者增多,需更改治疗方案。Objective To investigate the effect of hepatotoxicity of anti-tuberculosis on prognosis in standardized anti-tuberculosis treatment for AIDS/TB patients. Method Retrospectively analyzed 361AIDS/TB patients,and found out the incidence, degree, prognosis of hepatotoxicity after taking two months standardized anti-tuberculosis treatment. Meanwhile, withdrew 382 cases with TB positive and HIV negative at random as control group. Results The total incidence of hepatotoxicity in AIDS/TB group was 40.2%, and of severe hepato- toxicity wasl0.8%. The rate of treatment failure was 7. 8%, and lg. 4% of them changed therapeutic schedule. Meanwhile, The total inci- dence of hepatotoxicity in TB positive and HIV negative patients was 21.7% ,and of severe hepatotoxicity was 4. 5% ,with a rate of 0. 8% in treatment failure, and 5.2% of them changed therapeutic schedule. It was significantly different in those two groups. Conclusions More AIDS/TB patients were apt to hepatotoxicity, especially to those with a high risk of severe hepatotoxicity, which needed to change the therapeutic schedule and raise the treatment failure cases.

关 键 词：艾滋病 结核 抗结核药物 肝损伤 

分 类 号：R521[医药卫生—内科学]