新生儿血清25羟维生素D_3水平的动态变化及意义  

Level dynamic changes and significance of serum 25-(OH) D_3 in newborns

作　　者：李军军[1] 丁晓春[1] 

机构地区：[1]苏州大学附属儿童医院新生儿科,江苏苏州215003

出　　处：《中国儿童保健杂志》2012年第2期130-131,148,共3页Chinese Journal of Child Health Care

摘　　要：【目的】通过动态监测不同胎龄新生儿血清25羟维生素D3[25-(OH)D3]水平的变化,了解不同胎龄新生儿维生素D的营养状况,探讨外源性维生素D的补充时机。【方法】选择95例新生儿为研究对象,按胎龄分为3组:A组30例(胎龄≤33周),B组34例(33周<胎龄<37周),C组31例(37周≤胎龄<42周),于生后第1天、第14天及第30天检测血清25-(OH)D3水平。【结果】生后第1天A组血清(25-(OH)D3)平均浓度[(35.03±9.72)nmol/L]低于B组和C组血清(25-(OH)D3)平均浓度[(41.31±11.35)nmol/L和(42.05±15.93)nmol/L](P<0.05)。生后第1、14天及第30天各有76.8%、53.7%和75.8%的新生儿存在维生素D缺乏[25-(OH)D3<50nmol/L]。【结论】新生儿普遍存在维生素D缺乏,生后应尽早补充维生素D。【Objective】 To observe the changes of serum 25-（OH）D3 in newborns in different gestation ages,to know nutritional status of the vitamin D,and study exogenous vitamin D supplements.【Methods】 Ninety-five newborns were studied.All the newborns were divided into three groups according to gestational age：Group A had 30 newborns（GA≤33 weeks）,Group B had 34 newborns（33 weeksGA37 weeks）,Group C had 31 newborns（37 weeks≤GA42 weeks）.Serum 25-（OH）D3 was measured within 1 d,14 d,30 d after birth.【Results】 The mean serum 25-（OH）D3 concentration[（35.03±9.72） nmol/ L] of A group were lower than the mean serum 25-（OH）D3 concentration of B and C group[（41.31±11.35） nmol/L,（42.05±15.93） nmol/L]（P〈0.05）1 d after birth.76.8%,53.7% and 75.8% of newborns had vitamin D deficiency（serum 25-（OH）D3 levels 50 nmol/L）in 1 d,14 d and 30 d after birth.【Conclusion】 The vitamin D deficiency of newborns is common,and the vitamin D should be supplied as early as after birth.

关 键 词：新生儿 25-羟维生素D3 维生素D缺乏 

分 类 号：R179[医药卫生—妇幼卫生保健]