空肠内注入ω-3多不饱和脂肪酸对急性胰腺炎大鼠免疫功能的影响  

Effect of ω-3 polyunsaturated fatty acids injected into the jejunum on immune function in rats with actue pancreatitis

作　　者：田明[1] 陈振宙[1] 丁治国[1] 王广[1] 孙清露[1] 

机构地区：[1]北京中医药大学东直门医院普外科,北京100700

出　　处：《中国医药导报》2012年第4期26-27,29,共3页China Medical Herald

摘　　要：目的观察空肠内注入ω-3多不饱和脂肪酸对急性胰腺炎(AP)大鼠免疫功能的影响。方法将80只大鼠随机分为4组,分别为无胰腺炎组(对照组)、胰腺炎-普通营养组、胰腺炎-玉米油组和胰腺炎-鱼油组。建立急性胰腺炎模型,术后第7天检测各组外周血中IL-1β、IL-18、IL-10、TNF-α浓度和IL-10/TNF-α变化。结果胰腺炎-鱼油组大鼠IL-1β、IL-18、IL-10、TNF-α浓度和IL-10/TNF-α较其他组明显降低。结论空肠内注入ω-3多不饱和脂肪酸具有抑制急性胰腺炎大鼠炎症反应和维持抗炎促炎平衡状态作用。Objective To investigate the effect of ω-3 polyunsaturated fatty acids injected into the jejunum on immune function in rats with acute pancreatitis（AP）.Methods 80 rats were randomly divided into four groups： no-AP group,AP-commen enteral nutrition group,AP-corn oil group and AP-fish oil group.Both the value of IL-10/TNF-α and the concentration of IL-1β,IL-18,IL-10 and TNF-α were detected at the 7th day after established acute pancreatitis model.Results Both the value of IL-10/TNF-α and the concentration of IL-1β,IL-18,IL-10 and TNF-α were lower in AP-fish oil group rats.Conclusion ω-3 polyunsaturated fatty acids injected into the jejunum can decrease the inflammatory reaction and modulate the immune function in rats with acute pancreatitis.

关 键 词：Ω-3多不饱和脂肪酸 急性胰腺炎 免疫功能 

分 类 号：R657.51[医药卫生—外科学]