原发性高血压患者血压变异性与血清TNF-α、IL-6、hs-CRP关系的研究  

Research on the association between blood pressure variability and TNF-α,IL-6,hs-CRP in essential hypertension patients

作　　者：王家赐[1] 刘八一[1] 李建功[1] 

机构地区：[1]广东省中山市中医院综合科,广东中山528400

出　　处：《中国医药导报》2012年第5期39-41,共3页China Medical Herald

摘　　要：目的探讨原发性高血压患者血压变异性(blood pressure variability,BPV)和炎症标志物TNF-α、IL-6、hs-CRP之间的联系。方法 62例原发性高血压患者均进行24 h动态心血压监测和清晨空腹采血,采用双抗体夹心ABC-ELISA法检测血清IL-6和TNF-α水平;免疫透射比浊法检测血清高敏C反应蛋白(hs-CRP)水平。BPV通过计算标准差(standard deviation,s)和血压变异系数(coefficient of variation,CV)获得。结果血压(BP)和TNF-α表达水平明显相关;IL-6表达水平和日间收缩压的s和CV相关,但和BP没有相关性;hs-CRP与BP及血压的s和CV均无明显相关性。相关性分析显示,日间收缩压的s(β=0.066,P=0.002)和年龄(β=0.025,P=0.018)均与IL-6呈明显正相关;日间舒张压(β=0.031,P=0.002)独立相关于TNF-α。结论原发性高血压人群中BPV与炎症标志物存在相关关系,提示高血压和靶器官损伤之间的联系可能与炎症的发生发展相关。Objective To investigate the association between blood pressure variability（BPV） and inflammatory marker in hypertensive patients.Methods 62 cases of essential hypertension patients were performed 24 h ambulatory BP monitoring.Inflammatory markers were evaluated by measuring plasma levels of interleukin（IL）-6,tumornecrosis factor（TNF）-α by a dual antibody sandwich enzyme-linked immunosorbent assay（ELISA）;levels of high sensitive C-reactive protein（hs-CRP） were mesaured by immunoturbidimetry.BPV was obtained by calculating within-subject standard deviation（s） and coefficient of variation of BP.Results A significant association between ambulatory BP and TNF-α level was identified,while the BPV index was linked to IL-6 level,but no association was observed between BP and IL-6 level.However,no significant correlation was found between the hs-CRP concentration and the BP standard deviation or BP variability.Multiple linear regression models revealed that the s of daytime systolic BP（β=0.066,P=0.002） and age（β=0.025,P=0.018） were all positively and significantly related to IL-6.In contrast,only daytime diastolic BP（β=0.031,P=0.002） was independently related to TNF-α.Conclusion Infiammatory markers TNF-α,IL-6 are associated with BPV in essential hypertension patients.This finding implies that development of the infiammation would be correlated with the link between BPV and target organ damage.

关 键 词：原发性高血压 血压变异性 炎症 

分 类 号：R544.1[医药卫生—心血管疾病]