长期使用避孕药和宫内节育器妇女生殖道衣原体及人乳头瘤病毒检测  

Assay of chlamydia trachomatis and human papillomavirus in genital tract of women long-term using oral contraceptives and intrauterine devices

作　　者：吴玉璘[1,2] 石慧[1,2] 孙志明[1,2] 潘丽[1,2] 李瑛[1,2] 

机构地区：[1]江苏省计划生育科学技术研究所 [2]江苏省生殖健康检验中心,江苏南京210036

出　　处：《中国医药导报》2012年第5期81-83,共3页China Medical Herald

基　　金：江苏省科技支撑计划(社会发展)(BE2011807)

摘　　要：目的了解长期使用口服避孕药(OC)及宫内节育器(IUD)避孕妇女生殖道衣原体(CT)及人乳头状瘤病毒(HPV)感染的情况,指导计划生育优质服务。方法采用聚合酶链反应(PCR)检测服用口服避孕药、使用宫内节育器5年以上的妇女226例宫颈分泌物中CT及HPV DNA。研究对象按避孕措施分成1号片组、复方18-甲组和宫内节育器组。结果三组研究对象的CT总检出率为21.24%,1号片组为24.69%,复方18甲组为20.45%,IUD组为17.54%,CT检出率三组间的差异无统计学意义(P>0.05);三组研究对象的HPV总检出率为14.2%,1号片组为11.11%,复方18-甲组为20.45%,宫内节育器组为8.77%,三组间差异无统计学意义(P>0.05)。在CT及HPV感染者的阴道及宫颈异常方面三组比较差异无统计学意义(P>0.05),多数感染者无临床体征。结论加强对长期使用避孕措施妇女的随访服务,提供包括宫颈细胞学涂片检查、CT和HPV检测在内的生殖保健服务,保障避孕措施使用者的健康权益。Objective To understand the situation of the Chlamydia trachomatis（CT） and human papillomavirus（HPV） infection in women long-term using combined oral contraceptives（OC） or intrauterine device（IUD）,in order to guide quality of care in family planning.Methods Polymerase chain reaction（PCR） was performed for women who had long-term taken Combined Norethisterone,or Combined Norgestrel,or had worn the IUD for birth control.226 women were divided into three groups： Norethisterone group,Norgestrel group and IUD group.Results The total detectable rate of CT was 21.24% in all subjects,the rates were 24.69% in the Norethisterone group,20.45% in the Norgestrel group and 17.54% in the IUD group.The total detectable rate of HPV was 14.2% in all subjects,the rates were 11.11% in the Norethisterone,20.45% in the Norgestrel group and 8.77% in the IUD group.The rates of CT and HPV in the two OC groups were higher than that in the IUD group,but had no significant difference（P0.05）.There was no significant difference in clinical symptoms among the three groups（P0.05）.However,most of women with CT or HPV infections had no clinical symptoms.Conclusion Following up should be strengthened for women who use contraception method for long time.Reproductive health care services,including regular cervical smears,CT and HPV assay should be provided,especially for the long-term users of contraception methods to improve their physical and mental health.

关 键 词：口服避孕药 宫内节育器 衣原体 人乳头状瘤病毒 聚合酶链反应 

分 类 号：R173[医药卫生—妇幼卫生保健]