黄葵胶囊联合奥美沙坦治疗IgA肾病轻中度蛋白尿临床观察  

Clinical study of Huangkui Capsule combined with Olmesartan in the treatment of IgA nephropathy with mild to moderate proteinuria

作　　者：李六生[1,2] 闫翠平[1,2] 周志华[1,2] 

机构地区：[1]湖北省宜昌市第一人民医院 [2]三峡大学人民医院肾内科,湖北宜昌443000

出　　处：《中国医药导报》2012年第6期74-75,共2页China Medical Herald

摘　　要：目的观察黄葵胶囊联合奥美沙坦治疗IgA肾病轻中度蛋白尿的临床疗效。方法将60例经肾脏病理活组织检查确诊的IgA肾病患者随机分成两组,各30例,对照组奥美沙坦20 mg,1日1次口服治疗;治疗组黄葵胶囊5粒,1日3次口服,奥美沙坦20 mg,1日1次口服治疗,疗程均为12周,比较两组治疗前后血白蛋白、尿素氮、肌酐、纤维蛋白原(Fib)、24 h尿蛋白定量(UTP)的变化,并判断临床疗效。结果治疗12周后,治疗组总有效率(86.7%)明显优于对照组(63.3%)(P<0.05),两组治疗后UTP与本组治疗前比较差异有统计学意义(P<0.05,P<0.01),治疗组较对照组降低更显著(P<0.05),治疗组Fib较治疗前明显下降(P<0.05),与对照组相比差异有统计学意义(P<0.05)。结论黄葵胶囊联合奥美沙坦比单用奥美沙坦能更有效地降低IgA肾病蛋白尿,能降低血纤维蛋白原,副作用少,值得临床推广使用。Objective To observe the clinical efficacy of Huangkui Capsule combined with Olmesartan in the treatment of IgA nephropathy with mild to moderate proteinuria.Methods Sixty patients with IgA nephropathy proved by biopsy were randomly divided into treatment group and control group,each group contained 30 cases.The treatment group was treated with Huangkui Capsule（5 pills,three times a day） and Olmesartan（20 mg,once a day） for 12 weeks,while the control group was treated with Olmesartan（20 mg,once a day）.The changes of serum albumin、blood urea nitrogen、serum creatinine、fibrinogen（Fib） and 24 hours urinary total protein（UTP） in two groups were respectively compared before and after treatment.Results In 12 weeks after treatment,the treatment group total effective rate（86.7%） was higher than the control group（63.3%）（P〈 0.05）.UTP decreased significantly in two groups（P 〈0.05,P〈 0.01） and more significantly in treatment group than in control group（P〈 0.05）.Meanwhile the level of Fib declined greatly（P 〈0.05） compared with that before treatment in treatment group,and this change was also remarkably different compared with that in control group（P 〈0.05）.Conclusion Huangkui Capsule combined with Olmesartan is more effective in reducing proteinuria and Fib than Olmesartan in IgA nephropathy with mild to moderate proteinuria,with less side effect,it is worthy of clinical application.

关 键 词：黄葵胶囊 奥美沙坦 IGA肾病 蛋白尿 

分 类 号：R692.3[医药卫生—泌尿科学]