正常中晚期孕妇的凝血四项和D-二聚体结果分析及其临床意义  

Detection of Four Items Blood Coagulation and D-dimer in Women in Mid-late Pregnancy and its Clinical Significance

作　　者：王中东[1] 黄麦华[2] 

机构地区：[1]泰山疗养院,山东泰安271000 [2]泰安市中心医院

出　　处：《社区医学杂志》2012年第2期16-17,共2页Journal Of Community Medicine

摘　　要：目的检测正常中晚期孕妇的凝血四项及D-二聚体指标,了解正常中晚期孕妇的凝血与纤溶功能状态及临床意义。方法凝血四项测定均为凝固法,D-二聚体为免疫比浊法。在Sysmex CA7000全自动血凝仪上进行检测。结果正常妊娠中晚期孕妇与正常非孕妇女对照组比较,PT、APTT时间明显缩短(P<0.05);FIB显著增高(P<0.01);TT差异不明显(P>0.05);D-二聚体水平差异有统计学意义(P<0.05)。结论妊娠中晚期由于凝血功能增强,抗凝及纤溶功能减弱,出现妊娠期高凝状态,有利于产后快速有效止血。产前凝血功能的检测,对预防产科并发症(如DIC及羊水栓塞等)有重要的临床意义。Objective To detect the result of four items blood coagulation and plasma D - dimer in healthy women in mid - late women, so as to understand their coagulation and fibrinolysis. Methods Four items blood coagulation were assayed with coagulation method, and D - dimer with immune - turbidity method. Both were tested on sysmex Ca - 7000 full - Au- tomatic coagulation analyzer. Results Compared with the healthy non - pregnant women, women in mid - late pregnancy had shorter PT and APTF（ P 〈 O. 05 ）, and higher FIB （P 〈 O. 01 ）. There was no evident difference on TI＇ （P 〉 0.05 ）. The significant difference was also found in D - dimer level between the two groups （P 〈 0.05）. Conclusions Due to en- hanced coagulation and decreased fibrinolytic activity, hypercoagulability usually occurs in mid -late pregnancy, which is useful to stop post - partum bleeding rapidly and effectively. Therefore, it is clinically important to examine the coagulation function prenatally, especially to avoid obstetric complications such as DIC and amniotic fluid embolism.

关 键 词：中晚期孕妇 凝血四项 D-二聚体 

分 类 号：R714.1[医药卫生—妇产科学]