奶牛白细胞黏附缺陷症(BLAD)检测方法的研究进展  

Progress on the Study of the Test Methods for Bovine Leukocyte Adhesion Deficiency(BLAD)

作　　者：周莉[1,2] 贾广乐[1] 张映[2] 韩雪清[1] 林祥梅[1] 

机构地区：[1]中国检验检疫科学研究院,北京100121 [2]山西农业大学动物科技学院,山西太谷030801

出　　处：《中国畜牧兽医》2012年第2期137-140,共4页China Animal Husbandry & Veterinary Medicine

基　　金：五种牛隐性遗传缺陷病及布病检疫技术和标准研究(20120122);质检总局科研项目"奶牛两种隐性遗传疾病分子筛查方法的建立"(2011IK021)

摘　　要：奶牛白细胞黏附缺陷症是近年新发现的一种常染色体单基因隐性遗传病,由常染色体上CD18基因单碱基突变(A→G)引起的隐性遗传疾病,隐性基因纯合时导致白细胞表面的β2整合素表达明显减少或缺乏而引起临床发病,患病牛的主要特征是机体免疫力降低、易患病从而影响生产性能,严重影响了奶牛场的经济效益。文章综述了该病检测方法的研究进展。Bovine leukocyte adhesion deficiency（BLAD） is a newly discovered autosomal recessive genetic disease in recent years caused by A→G mutation in the CD18 gene.The disease is characterized by greatly reduced expression of the hetero dimeric β2 integrin adhesion molecules on leukocytes resulting in multiple defects in leukocyte function and significant deficits on performance traits in Holstein cattle.The main features of sick cattle is immunity reduction,susceptibility to diseases and affecting production performance.This review focus on the progress of test methods of BLAD.

关 键 词：白细胞黏附缺陷症 检测方法 研究进展 

分 类 号：S858.23[农业科学—临床兽医学]