卷柏化学成分及细胞毒活性研究(英文)  

Cytotoxic Constituents from Selaginella tamariscina

作　　者：曹园[1] 吴永平[2] 温晓舟[1] 翁燕[1] 王强[3] 

机构地区：[1]江苏省中医院中药制剂实验室,江苏省中医院肿瘤临床研究中心,南京210036 [2]江苏省药物研究所 [3]中国药科大学中药分析教研室,南京210009

出　　处：《天然产物研究与开发》2012年第2期150-154,共5页Natural Product Research and Development

摘　　要：从卷柏(Selaginella tamariscina(Beauv.)Spring)中分离得到10个化合物,运用波谱手段分别鉴定为se-laginellin(1)、selaginellin A(2)、selaginellin B(3)、穗花杉双黄酮(4)、sequoiaflavone(5)、去甲银杏双黄酮(6)、银杏双黄酮(7)、异银杏双黄酮(8)、扁柏双黄酮(9)、异柳杉双黄酮(10)。其中化合物1、5和8为首次从该植物中分离得到。化合物1,4,7,8和9显示出选择性的细胞毒活性。Three selaginellins and seven biflavones were isolated from the whole plant of Selaginella tamariscina.Their structures were identified as selaginellin（1）,selaginellin A（2）,selaginellin B（3）,amentoflavone（4）,sequoiaflavone（5）, bilobetin（6）,ginkgetin（7）,isoginkgetin（8）,hinokiflavone（9）,and isocryptomerin（10）.Among them,compounds 1,5,and 8 were isolated from this plant for the first time.Additionally,selected compounds were evaluated for their cytotoxic activity against tested human cell lines,and compounds 1,4,7,8 and 9 showed selective cytotoxic activity.

关 键 词：卷柏 化学成分 selaginellins 双黄酮 细胞毒活性 

分 类 号：R284.1[医药卫生—中药学] Q946.91[医药卫生—中医学]