Pressured Microwave-assisted Hydrolysis of Crude Glycyrrhizic Acid for Preparation of Glycyrrhetinic Acid  

加压微波辅助水解甘草酸粗品制备甘草次酸(英文)

作　　者：王仁敏 林婵 刘晶靓 余方 高建培 潘学军 

机构地区：[1]Faculty of Environmental Science and Engineering,Kunming University of Science and Technology

出　　处：《Chinese Journal of Chemical Engineering》2012年第1期152-157,共6页中国化学工程学报（英文版）

基　　金：Supported by the Yunnan Provincial Department of Education Key Foundation (07Z10311)

摘　　要：A pressured microwave-assisted hydrolysis （PMAH） technique has been developed for hydrolyzing the crude glycyrrhizic acid （GA） extracted from licorice root to prepare glycyrrhetinic acid （GRA）. In order to optimize the efficiency of PMAH, several experimental parameters were investigated, including liquid-solid ratio, hydrolysis time, sulfuric acid concentration and hydrolysis temperature. The optimized hydrolysis conditions were as follows：pressured microwave-assisted hydrolysis of crude GA for 21 min （taking 15 min to reach 150 ℃, and holding it for 6 rain） at 150 ℃ （at a radiation power of 450 W） in 3%-5% sulfuric acid solution with the liquid-solid （ml.g-1 crude GA） ratio of 25 ： 1. As a result of the considerable saving in time and higher product yields （up to 90%）, PMAH was proved more effective than conventional methods.A pressured microwave-assisted hydrolysis(PMAH) technique has been developed for hydrolyzing the crude glycyrrhizic acid(GA) extracted from licorice root to prepare glycyrrhetinic acid(GRA).In order to optimize the efficiency of PMAH,several experimental parameters were investigated,including liquid-solid ratio,hydrolysis time,sulfuric acid concentration and hydrolysis temperature.The optimized hydrolysis conditions were as follows:pressured microwave-assisted hydrolysis of crude GA for 21 min(taking 15 min to reach 150 oC,and holding it for 6 min) at 150 oC(at a radiation power of 450 W) in 3%-5% sulfuric acid solution with the liquid-solid(ml?g?1 crude GA) ratio of 25︰1.As a result of the considerable saving in time and higher product yields(up to 90%),PMAH was proved more effective than conventional methods.

关 键 词：glycyrrhetinic acid glycyrrhizic acid licorice root pressured microwave-assisted hydrolysis highperformance liquid chromatography 

分 类 号：TQ464[化学工程—制药化工]