POLY(N-VINYLPYRROLIDONE)-MODIFIED SURFACES REPEL PLASMA PROTEIN ADSORPTION  

作　　者：武照强 

机构地区：[1]College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Soochow 215123,China

出　　处：《Chinese Journal of Polymer Science》2012年第2期235-241,共7页高分子科学（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.20974086,20974122 and 20920102035);the Ministry of Education of China(209151);the Scientific Research Foundation for the Returned Overseas Chinese Scholars and State Education Ministry

摘　　要：The present work aimed to study the interaction between plasma proteins and PVP-modified surfaces under more complex protein conditions. In the competitive adsorption of fibrinogen （Fg） and human serum albumin （HSA）, the modified surfaces showed preferential adsorption of HSA. In 100% plasma, the amount of Fg adsorbed onto PVP-modified surfaces was as low as 10 ng/cm2, suggesting the excellent protein resistance properties of the modified surfaces. In addition, immunoblots of proteins eluted from the modified surfaces after plasma contact confirmed that PVP-modified surfaces can repel most plasma proteins, especially proteins that lalav important roles in the nrocess of blood coagulation.The present work aimed to study the interaction between plasma proteins and PVP-modified surfaces under more complex protein conditions. In the competitive adsorption of fibrinogen （Fg） and human serum albumin （HSA）, the modified surfaces showed preferential adsorption of HSA. In 100% plasma, the amount of Fg adsorbed onto PVP-modified surfaces was as low as 10 ng/cm2, suggesting the excellent protein resistance properties of the modified surfaces. In addition, immunoblots of proteins eluted from the modified surfaces after plasma contact confirmed that PVP-modified surfaces can repel most plasma proteins, especially proteins that lalav important roles in the nrocess of blood coagulation.

关 键 词：Poly（N-vinylpyrrolidone） Surface modification Protein adsorption ATRP Biocompatibility. 

分 类 号：O631.3[理学—高分子化学]