甘草酸二铵脂质复合物对大鼠非酒精性脂肪肝的治疗效果研究  

Effects of diammonium glycyrrhizinate phosphatidylcholine complex treatment on rat nonalcoholic fatty liver disease

作　　者：程勇[1] 于锋[1] 

机构地区：[1]中国药科大学临床药学教研室

出　　处：《中国临床药理学与治疗学》2012年第1期15-19,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:研究甘草酸二铵脂质复合物(甘平,DGLL)对大鼠非酒精性脂肪肝(NAFLD)的治疗作用。方法:以高脂饲料喂养方式建立大鼠非酒精性脂肪肝模型,证实造模成功后随机分为空白对照组、模型组、多烯磷脂酰胆碱组和甘平高中低(900、300、100mg/kg)剂量组。给药4周后,处死所有动物,检测血脂、氧化应激、肝功能、胰岛素相关等指标,并观察肝脏组织病理学变化。结果:甘平能显著降低NAFLD大鼠的转氨酶(ALT、AST)活力、丙二醛(MDA)含量、TNF-α水平、空腹血糖(FBG)、空腹胰岛素(FINS)水平和空腹胰岛素抵抗指数(HOMA-IR),升高超氧化物歧化酶(SOD)活力,改善NAFLD大鼠的总胆固醇(TC)、甘油三酯(TG)水平。结论:甘平可以用来治疗大鼠NAFLD,其机制可能与抗氧化作用及改善胰岛素抵抗有关。ABSTRACT AIM. To observe the therapeutically effect of diammonium glycyrrhizinate phos- phatidylcholine complex （DGLL） on the non alcoholic fatty liver disease （NAFLD）. METHODS： NAFLD rat model was constructed by feeding rats with high fatty and cholesterol diet for 8 weeks. And NAFLD model was subdivided into 6 subgroups： control group, model group, polygene phosphatidylcholine capsules group and DGLL groups （100,300,900 mg/kg）. At the end of 12 week, all rats were killed to detect the blood lipids, oxidative stress, liver function, insulin-related and the pathological changes. RE- SULTS： DGLL could significantly reduce the NAFLD rats aminotransferase （ALT, AST） activity, malondialdehyde （MDA） content, TNF-alevel, fasting blood glucose （FBG）, fasting in- sulin （FINS） level and fasting insulin resistance index （HOMA-IR）. DGLL could also increase superoxide dismutase （SOD） activity and improve NAFLD rats total cholesterol （TC） and triglyceride （TG） levels. CONCLUSION： DGLL can be used to treat NAFLD, and the mechanism may be related to lowering blood lipids and improving liver function, anti-oxidation and insulin resistance.

关 键 词：非酒精性脂肪肝 甘草酸二铵脂质复合物 脂质过氧化 氧化应激 胰岛素抵抗 

分 类 号：R965.2[医药卫生—药理学]