药理效应法测定参附注射液药动学参数的研究  

Study on determining pharmacokinetics parameters of Shenfu injection by pharmacology effect method

作　　者：杜婷[1] 孙荣进[2] 徐国良[1] 李冰涛[1] 黄丽萍[3] 李佳[1] 

机构地区：[1]江西中医学院现代中药制剂教育部重点实验室 [2]湖北医药学院药学院 [3]江西中医学院药理教研室

出　　处：《中国临床药理学与治疗学》2012年第1期69-72,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金项目(30960513);国家重点基础研究发展计划(973计划)(2010CB530603)

摘　　要：目的:考察参附注射液在大鼠体内的药动学特征。方法:采用结扎冠状动脉法复制大鼠心源性休克模型,以血压值作为效应指标,选取1.25、2.5、5、10、20、25mL/kg六个剂量参附注射液做量-效曲线,选择20mL/kg剂量做时-效曲线,依据时-效曲线和量效曲线求得时间-生物体存量曲线,用DASver 2.0软件分析参附注射液的药动学参数。结果:主要药物动力学参数为t1/2=8.685min,Ke=0.08min-1,CL=1.417L.min-1.kg-1,AUC(0-t)=12.63mg.L-1.min-1。结论:在大鼠体内静脉注射参附注射液的体存量的表观动力学过程符合一室模型。ABSTRACT AIM： To determine pharmacoki netics parameters of Shenfu injection with pharmacodynamics effect. METHODS： Model of acute cardiogenic shock was made by ligating left coronary artery. Mean blood pressure （MBP） was as effective index. Dose-response curves were established with 1.25, 2.5, 5, 10, 20, 25 mL/kg six doses and time-course effects were established with the 20 mL/kg dose. The time- stock of organisms curves were calculated with the time-course effects and dose-response curves. The pharmacokinetic parameters ofShenfu injection were analysed with DASver2.0 software. RESULTS：The main pharmaeokinetics parameters were： t1/2-8.685min,Ke=0.08min^-1,CL=1.417L·min^-1·kg^-1,AUC（0-t）=12.63mg·L^-1·min^-1. CONCLU- SION： Apparent pharmacokinetic of Shenfu injection in rats fit one compartment.

关 键 词：参附注射液 药物动力学 药理效应法 

分 类 号：R965.2[医药卫生—药理学]