生物被膜主动分散机制研究进展  

Advance in Active Biofilm Dispersal Mechanism

作　　者：高宗良[1] 谷元兴[1] 赵峰[1] 刘永生[1] 

机构地区：[1]中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室、农业部畜禽病毒学重点开放实验室、农业部兽医公共卫生重点开放实验室,兰州730046

出　　处：《中国生物工程杂志》2012年第2期117-122,共6页China Biotechnology

基　　金：国家自然科学基金资助项目(31172335/C1805)

摘　　要：细菌生物被膜(bacterial biofilm,BBF)为微生物栖息提供了所需要的保护屏障和生长微环境。生物被膜对抗菌药物的耐受性使得它在医学治疗等领域产生了严重的危害。因此如何分散被膜显得意义重大。综述了生物被膜主动分散的几种主要机制,包括降解酶的合成、运动力的恢复、表面活性剂的产生和细胞死亡。Microbial biofilms are composed of a hydrated matrix of biopolymers including polypeptides, polysaccharides and nucleic acids and act as a protective barrier and microenvironment for the inhabiting microbes. The resistantce of biofilms to antimicrobial agents leads to a range of problems, including medical treatment, which highlights the significance of biofilm dispersal. The mechanisms that result in active dispersal of bacteria from biofilm, which include the synthesis of enzymes, the return of motility, surfactant production and cell lysis were reviewed.

关 键 词：被膜分散降解酶种子分散细胞死亡 

分 类 号：Q939.93[生物学—微生物学]