100Hz电针对大鼠可卡因CPP重建的影响  

The effect of 100 Hz electroacupuncture on cocaine-induced CPP reinstatement in rats

作　　者：侯炳军 

机构地区：[1]山东医学高等专科学校,山东276000

出　　处：《中国药物滥用防治杂志》2012年第1期11-13,16,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨100Hz电针对大鼠可卡因条件位置偏爱(Conditioned Place Preference,CPP)重建的影响。方法:采用可卡因诱导大鼠CPP重建模型,观察100Hz电针对大鼠可卡因CPP重建的作用及选择性κ阿片受体拮抗剂nor-BNI对电针作用的影响。结果:100Hz电针5次刺激抑制了可卡因(5mg/kg)引燃CPP重建,nor-BNI(10μg/5μl)翻转了电针对可卡因CPP重建的抑制作用。结论:多次电针可通过κ阿片受体抑制可卡因引燃CPP的重建。Objective：To investigate the effect of 100 Hz electroacupuncture on cocaine conditioned place preference （CPP） reinstatement in rats. Methods：With cocaine-induced CPP reinstatement model in rats, we explore the effect of 100 Hz electroacupuncture on cocaine CPP reinstatement, and the influence of nor-BNI, a selective kappa-opioid antagonist, on the electroacupuncture role to the cocaine CPP reinstatment. Results： Five times of 100 Hz electroacupuncture could block the cocaine CPP reinstatment primed by 5 mg/kg; The effect of lOOHz electroacupuncture on cocaine CPP reinstatement could be reversed by pretreatment of nor-BNI （10 μg/ 5 μl,i, c. v）. Conclusion ：Repeated electroacupuncture can inhibit cocaine CPP reinstatement by kappa-opioid receptor.

关 键 词：可卡因 电针 条件位置偏爱 重建 

分 类 号：R245[医药卫生—针灸推拿学]