类风湿性关节炎滑膜组织中PTTG1和MMP-2的表达及意义  

Expression of PTTG-1 and MMP-2 and their biological significance in synoviun of rheumatoid arthritis

作　　者：王艳霞[1] 王瑞琳[2] 赵莉莉 熊光宜[2] 徐瑾[2] 魏典[2] 李兰萍[2] 

机构地区：[1]天津医科大学研究生院,天津300070 [2]天津市天津医院病理科,天津300211 [3]北京市丰台医院病理科,北京100070

出　　处：《临床与实验病理学杂志》2012年第2期166-169,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的检测类风湿性关节炎(rheumatoid arthritis,RA)患者滑膜被覆细胞及滑膜下组织中垂体肿瘤转化基因1(pituitarytumor transforming gene 1,PTTG1)及MMP-2的表达及分布状况,探讨其在RA发病中的作用。方法采用免疫组化SP法检测68例RA患者,14例骨性关节炎(osteoarthritis,OA)患者滑膜被覆细胞及滑膜下组织中PTTG1及MMP-2的表达状况。结果 PTTG1在RA组、OA组阳性率分别为64.7%和21.4%;MMP-2在RA组、OA组阳性率分别为73.5%和28.6%,差异具有统计学意义(P<0.05),且PTTG1和MMP-2之间表达具有相关性(rs=0.776,P<0.05)。结论 PTTG1和MMP-2在RA组滑膜组织的表达均明显升高,且二者之间的表达具有相关性,从而证实其在RA的发病机制中可能具有一定的作用。Purpose To detect the expression and distribution of PTTG1 and MMP-2 in synovial tissue of rheumatoid arthritis and to discuss their roles in the mechanism of rheumatoid arthritis.Methods SP immunohistochemical method was used to detect the expression of PTTG1 and MMP-2 in synovium of 68 rheumatoid arthritis cases and 14 osteoarthritis cases.Results The positive rates of PTTG1 were 64.7% in RA groups and 21.4% in OA groups.The positive rates of MMP-2 were 73.5% in RA groups and 28.6% in OA groups.The expression of PTTG1 in RA group was significantly higher than that of OA group.The expression of MMP-2 in RA group was significantly higher than that of OA group.And there was correlation between PTTG1 and MMP-2.Conclusion The expression of both PTTG1 and MMP-2 increases in synovium of RA and there is significant correlation between them,which thereby suggests that they may have certain association in the pathogenesis of rheumatoid arthritis.

关 键 词：类风湿性关节炎 滑膜 PTTG1 MMP-2 免疫组织化学 

分 类 号：R684.3[医药卫生—骨科学]