酮咯酸联合解痉药物治疗急性结石性肾绞痛的疗效评估  

Evaluation of the clinical effects using ketorolac tromethamine combined spasmolytic for acute calculous renal colic

作　　者：吴杰英[1] 温星桥[1] 方友强[1] 胡祥华[2] 戴海涛[2] 邢邦荣[2] 孔庆磊[2] 韩建华[2] 叶志强[2] 

机构地区：[1]中山大学附属第三医院泌尿外科,广州510630 [2]中山大学附属第三医院急诊外科,广州510630

出　　处：《中华腔镜泌尿外科杂志（电子版）》2012年第1期41-43,共3页Chinese Journal of Endourology(Electronic Edition)

摘　　要：目的评估酮咯酸联合解痉药物在急性结石性肾绞痛治疗中的作用。方法对403例急性结石性肾绞痛患者肌注酮咯酸氨丁三醇及654-2,并静脉滴注诺仕帕,补液500～1000ml。应用视觉模拟评分法分别评估治疗前后疼痛程度,记录副反应及初次治疗后72h内疼痛复发的情况。结果 352例(87.3%)显效,27例(6.7%)部分显效,24例(6.0%)无效。8例(2.0%)出现轻微中枢神经系统症状,10例(2.5%)出现轻微胃肠道症状,13例(3.2%)出现轻微迷走神经抑制症状。12例(3.0%)于离院72h内疼痛再发。结论酮咯酸联合解痉药物并适当补液,疗效好,副反应少,镇痛效果持久,是治疗急性结石性肾绞痛的有效选择。Objective To evaluate the clinical effects of ketorolac tromethamine combined spas- molytic for the treatment of acute calculous renal colic. Methods A total of 403 cases of acute renal colic caused by stones were treated with intramuscular ketorolac tromethamine combined 654-2, and then with intravenous infusion of drotaverine. Visual analog scale （VAS） was used to assess the pain levels before and after treatment. Side effects and pain relapse within 72 hours were recorded after the initial treatments. Results Three hundred and fifty-two cases （37.3%） were cured and 27 cases （6.7%） were partially cured, 24 cases （6.0%） were noneffective. Eight cases （2.0%） suffered from mild central nervous system symptoms, 10 patients （2.5%） had mild gastrointestinal symptoms, 13 patients （3.2%） had mild vagal inhibition symptoms. Twelve cases （3.0%） experienced pain recurrence within 72 hours after discharge from the hospital. Conclusions Ketorolac tromethamine combined spasmolytic is a better choice to treat acute calculous renal colic, with good efficacy, less side effects and durable analgesic effects.

关 键 词：肾绞痛 结石 酮咯酸 镇痛 

分 类 号：R691.4[医药卫生—泌尿科学]