子宫内膜自然杀伤细胞与药物流产出血关系的研究  

THE RELATIONAL RESEARCH OF NATURAL KILLER CELL IN ENDOMETRIUM AND VAGINAL BLEEDING AFTER MEDICAL ABORTION

作　　者：魏静波[1] 刘辉[1] 曲银娥[1] 田艳霞[1] 

机构地区：[1]河北联合大学基础医学院组织胚胎学教研室,河北省唐山市063000

出　　处：《中国煤炭工业医学杂志》2012年第2期159-161,共3页Chinese Journal of Coal Industry Medicine

基　　金：唐山市科学技术与发展规划基金(10140201A-13)

摘　　要：目的探讨米非司酮药物流产后子宫出血与子宫内膜自然杀伤细胞(uNK)的关系。方法选取自愿终止妊娠的停经8周之内的早孕妇女,自愿选择药物流产或人工流产二种方法,分为负压吸引人工流产组、药流不完全组(出血组)、药流完全组。收集三组蜕膜组织进行甲醛固定,石蜡包埋,uNK细胞的表达采用免疫组化染色,图象分析仪定量分析。结果米非司酮药流不完全出血区uNK细胞的数量多于药流不完全非出血区、药流完全组及人流组,差异具有统计学意义(P<0.05)。药流完全组uNK细胞的数量多于人流组,二者间差异有统计学意义(P<0.01)。结论米非司酮的作用可以使uNK细胞数量异常增多,使子宫局部微环境发生改变,导致异常血管生成,孕囊与蜕膜剥离不全,从而引起出血。Objective To study the relationship of uterine blooding following mifespristone abortion to the nature killer cells in endometrium （the uNK cells）. Methods Healthy pregnant women required terminationwith gestational age less than 8 weeks were recruited. Methods of medical or surgical abortion were selected at women＇s own will. Divided three groups： surgical abortion by vaccum aspiration group, ineomplete abortion mifepristone group and complete abortion mifepristone group . Collect decidua of three groups to formalin- fixed paraffin- embeded. The expressions of CD56 are detected with immunohistochemical methods and the results are analyzed by using semi- quantitative image analysis equipment. Resuits In the bleeding area of the drug incomplete abortion group, the quantity of the uNK cells is increased greatly（P〈0. 05） . Compared with the surgical abortion group, the quantity of the uNK cells is increased greatly in the medical abortion group（P〈0.01）. Conclusion In the bleeding area of the drug incomplete abortion group, the quantity of the uNK cells is increased greatly cause abnormal vascularization, incomplete deprivation of pregnant sac or deciduas and bleeding.

关 键 词：米非司酮 子宫出血 子宫内膜自然杀伤细胞 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]