α-倒捻子素耐缺氧作用的初步研究  

Study on anti-anoxia effect of α-mangostin

作　　者：王碧琼[1] 

机构地区：[1]浙江黄岩中医院,黄岩318020

出　　处：《海峡药学》2012年第1期30-32,共3页Strait Pharmaceutical Journal

摘　　要：目的研究α-倒捻子素对缺氧小鼠的作用。方法小鼠给予α-倒捻子素一定时间后,采用亚硝酸盐建立缺氧模型,考察小鼠的生存时间。结果α-倒捻子素高剂量条件下可以显著延长小鼠的生存时间。结论α-倒捻子素具有一定的耐化学缺氧作用,可以用于缺氧、缺血性损伤的保护,具体作用机制有待进一步研究。OBJECTIVE To investigate the effects of α-mangostin on anoxic mice. METHODS By the ways of NaNO2 poisoning, the effect of α-mangostin on survival time was observed. RESULTS α-Mangostin at high dose could prolong the survival time in anoxic mice. CONCLUSION α-mangostin has the effect of anti-anoxia and can be used in anti-anoxia and ischemic injury. Its mechanism requires further research.

关 键 词：α-倒捻子素 亚硝酸盐 化学缺氧 

分 类 号：R282.710.5[医药卫生—中药学]