阳极吸附伏安法测定盐酸莫西沙星  

Anodic Adsorptive Voltammetric Determination of Moxifloxacin Hydrochloride

作　　者：龙宁[1] 朱明芳[1] 严志红[1] 邹艳[1] 

机构地区：[1]广东药学院药科学院,广州510006

出　　处：《理化检验（化学分册）》2012年第1期37-39,共3页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

摘　　要：提出了阳极吸附伏安法测定盐酸莫西沙星的方法。在pH 6.55的B-R缓冲溶液中,开路富集120s后,盐酸莫西沙星在碳糊电极表面于0.987V(vs.SCE)处产生一灵敏的氧化峰,该氧化峰电流与盐酸莫西沙星浓度在5.6×10-7～1.0×10-5 mol.L-1范围内呈线性关系,其检出限(3s/k)为4.3×10-8 mol.L-1。方法用于模拟片剂样品中盐酸莫西沙星的测定,测定值与标示值相符,其相对标准偏差(n=6)为3.8%,以健康人尿液为基体做加标回收试验,测得平均回收率为101.6%。Anodic adsorptive voltammetry was applied to the determination of moxifloxacin hydrochloride（MF）.In a B-R buffer solution of pH 6.55,the adsorptive voltammetric behavior of MF at the carbon paste electrode was studied after open-circuit accumulation for 120 s,a sensitive oxidation peak was observed at 0.987 V（vs.SCE）.Linear relationship between values of oxidation peak current and concentration of MF was kept in the range of 5.6×10-7-1.0×10-5mol·L-1.Detection limit（3s/k） found for the method was 4.3×10-8mol·L-1.The proposed method was used in the determination of MF in its tablets,giving results in consistency with the labelled value,with values of RSD′s（n=6） 3.8%.Recovery was tested by addition of standards to urine sample of healthy person,and the result of average recovery found was 101.6%.

关 键 词：盐酸莫西沙星 阳极吸附伏安法 碳糊电极 

分 类 号：O657.14[理学—分析化学]