Synthesis and characterization of bifunctional terbium complex-based nanoparticles  

作　　者：RuiHua Lu Jiang He LiZhen Huang Xia Ge XiaoYan Du Jie Zhu 

机构地区：[1]Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

出　　处：《Chinese Science Bulletin》2012年第7期750-755,共6页

基　　金：supported by the National Natural Science Foundation of China (J0730425);the Main Natural Science Foundation of Gansu Province in China (3ZS041-A25-009)

摘　　要：Novel bifunctional terbium complex-based nanoparticles were developed using a modified Stber method and a layer-by-layer assembly process. A magnetic core of Fe3O4 nanoparticles was coated with a silica shell to form the first layer. Then a ternary Tb3+ complex (TESPPA-Tb), which acted as a luminescent marker, was covalently bound to the silica surface by stable Si-O-Si bonds. The TESPPA monomer was synthesized by binding pyridine 2,6-dicarboxylic acid to 3-aminopropyltriethoxysilane, which was used as a ligand for coordination with the Tb3+ ions. An outer shell of silica was applied to the nanoparticles to allow for versatility with surface functionalization. The nanoparticles were characterized by X-ray powder diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, ultravioletvisible spectroscopy, vibration sample magnetometer, and photoluminescence spectroscopy. The bifunctional nanoparticles exhibited favorable superparamagnetic behavior and photoluminescence properties of Tb3+. These nanoparticles have potential applications in biolabeling, bioseparation, immunoassays, and pathogenic diagnosis.Novel bifunctional terbium complex-based nanoparticles were developed using a modified St0ber method and a layer-by-layer assembly process. A magnetic core of Fe304 nanoparticles was coated with a silica shell to form the first layer. Then a ternary Tb3＋ complex （TESPPA-Tb）, which acted as a luminescent marker, was covalently bound to the silica surface by stable Si-O-Si bonds. The TESPPA monomer was synthesized by binding pyridine 2,6-dicarboxylic acid to 3-aminopropyltriethoxysilane, which was used as a ligand for coordination with the Tb3＋ ions. An outer shell of silica was applied to the nanoparticles to allow for ver- satility with surface functionalization. The nanoparticles were characterized by X-ray powder diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, ultraviolet-visible spectroscopy, vibration sample magnetometer, and pho- toluminescence spectroscopy. The bifunctional nanoparticles exhibited favorable superparamagnetic behavior and photolumines- cence properties of Tb3＋. These nanoparticles have potential applications in biolabeling, bioseparation, immunoassays, and patho- genic diagnosis.

关 键 词：纳米粒子 铽离子 双功能 傅立叶变换红外光谱 表征 合成 X-射线粉末衍射 透射电子显微镜 

分 类 号：TQ426.94[化学工程] TB383[一般工业技术—材料科学与工程]