桑元止渴胶囊成型工艺研究  

Formulation process of Sangyuan Zhike Jiaonang

作　　者：陈强[1] 郑鹏成[1] 罗新根[1] 

机构地区：[1]广州军区广州总医院药学部,广州510010

出　　处：《中南药学》2012年第1期7-9,共3页Central South Pharmacy

基　　金：广东省科技计划项目(项目编号:2008A030201031)

摘　　要：目的确定桑元止渴胶囊剂成型工艺条件。方法以体止角、吸湿性、堆密度、临界相对湿度为考察指标,筛选出其处方中加入辅料的品种、配比及其最佳成型工艺,确定胶囊型号及装药量。结果微晶纤维素为辅料抗湿性能较好,桑元止渴胶囊的最佳成型工艺为:浸膏粉与辅料按8∶2的比例混匀,加入0.5倍95%乙醇制软材;制得颗粒流动性较好,临界相对湿度为68%,堆密度为0.726g.mL-1,选用0号胶囊,每粒装0.5g。结论该成型工艺合理、可行,为大生产提供了科学依据。Objective To study the production process of Sangyuan Zhike Jiaonang. Methods The best production process was determined by surveying the physical characteristics such as angle of repose,pile-density,critical relative humidity and hygroscopicity. Results Microcrystalline cellulose as excipients had a good anti-wet performance.The extract powder and microcrystalline cellulose were mixed evenly at 8∶2,and 95% alcohol was used as the wetting agent.The granules of end product had a good fluidity,the critical relative humidity was about 68%,bulk density was 0.726 g·mL-1,and 0.5 g was contained in each size 0 capsule. Conclusion The molding technology is reasonable,and can provide reliable basis for mass production.

关 键 词：桑元止渴胶囊 成型工艺 临界相对湿度 

分 类 号：R944.5[医药卫生—药剂学]