血根碱-黄芩苷、白屈菜红碱-黄芩苷离子对化合物体外抗菌活性和急性毒性研究  

In vitro antibacterial activity and acute toxicity of ion-pair compounds sanguinarine-baicalin and chelerythrine-baicalin

作　　者：徐丽[1,2] 曾建国[2,3] 程辟[2,3] 肖俐[1,2] 赵静[3] 刘秀斌[3] 

机构地区：[1]湖南中医药大学,长沙410208 [2]湖南省中药提取工程研究中心,长沙410331 [3]湖南农业大学,长沙410007

出　　处：《中南药学》2012年第1期10-13,共4页Central South Pharmacy

基　　金：国家科技部国际科技合作计划(编号:2010DFA32810);国家科技支撑计划(编号:2011BAD34B02)

摘　　要：目的对血根碱-黄芩苷、白屈菜红碱-黄芩苷2个离子对化合物进行体外抗菌、急性毒性研究。方法采用试管稀释法和琼脂平板扩散法测定血根碱-黄芩苷、白屈菜红碱-黄芩苷2个离子对化合物的最低抑菌浓度(MIC)和最小杀菌浓度(MBC),并进行急性毒性试验。结果血根碱-黄芩苷、白屈菜红碱-黄芩苷2个离子对化合物的MIC和MBC与黄芩苷、血根碱和白屈菜红碱相比降低,2个离子对化合物都无明显毒性。结论血根碱-黄芩苷、白屈菜红碱-黄芩苷离子对化合物体外抗菌活性增强,毒性减小,为新型抗菌药物的筛选奠定了基础。Objective To study the in vitro antibacterial and acute toxicities of ion-pair compounds sanguinarine-baicalin and chelerythrine-baicalin. Methods The minimum inhibitory concentration and minimum bactericidal concentration were tested by tube dilution method and agar plate diffusion method,and acute toxicity was studied. Results The minimum inhibitory concentration and minimum bactericidal concentration of sanguinarine-baicalin and chelerythrine-baicalin were lower than baicalin,sanguinarine and chelerythrine.No significant acute toxicity was found in these two ion-pair compounds. Conclusion In vitro antibacterial activities of sanguinarine-baicalin and chelerythrine-baicalin are increased while acute toxicities reduced,which lays a foundation for screening new antibacterial drugs.

关 键 词：离子对化合物 体外抗菌试验 急性毒性试验 血根碱-黄芩苷 白屈菜红碱-黄芩苷 

分 类 号：R965[医药卫生—药理学]