幽门螺杆菌感染与冠心病的相关性  

Relationship between Helicobacter pylori infection and coronary artery disease

作　　者：啜玉彩[1] 宋宏鲁 薛明涛[1] 宁晓喧[1] 何争[3] 李源[1] 王晓明[1] 

机构地区：[1]第四军医大学西京医院老年病科 [2]解放军66220部队医院 [3]第四军医大学西京医院心脏内科

出　　处：《心脏杂志》2012年第1期57-59,共3页Chinese Heart Journal

摘　　要：目的:探讨幽门螺杆菌(helicobacter pylori,Hp)感染与冠心病之间的关系。方法:研究对象分为:正常对照组(88例)和冠心病组(175例),正常对照组为冠状动脉造影(CAG)正常者;冠心病组经CAG证实冠状动脉狭窄程度超过50%,且排除Hp感染根治史或者恶性肿瘤的病史。我们通过胃十二指肠镜活检制作胃窦部组织切片,War-thin-starry银染色确定Hp感染。结果:两组间观测指标性别、年龄、吸烟和高密度脂蛋白胆固醇(HDL-C)差异具有统计学意义。正常对照组中28例(32%)和冠心病组73例(42%)伴有Hp感染,但差异不具有统计学意义。随访行经皮冠状动脉介入治疗的冠心病患者82例,半年复查CAG,59例Hp阴性的患者有21例(36%)出现新的冠状动脉病变或支架内再狭窄,23例Hp阳性的患者有12例(52%)出现新的冠状动脉病变或支架内再狭窄,两组间差异不具有统计学意义。结论:本研究没有明确Hp感染与冠心病的关系,有待进一步研究。AIM：To investigate the relationship between Helicobacter pylori（Hp） infection and coronary artery disease（CAD）.METHODS：There were 263 cases divided into two groups.There were 88 cases in the normal group and 175 cases in the CAD group.Patients in the CAD group had 50% coronary stenosis diagnosed by coronary angiography.Those patients with a history of previous Hp eradication and/or malignancy were ruled out.The tissue was acquired by gastroduodenoscopic biopsy and then stained by Warthin-starry silver stain.RESULTS：There were significant differences between groups in gender,age,smoking habit and high-density lipoprotein cholesterol（HDL-C）.There was no statistical difference in Hp infection ratio between groups（32% vs.42%）.Six months later,82 patients of the CAD group who had been treated by percutaneous coronary intervention（PCI） experienced angiography once again.Twenty-one（36%） of the 59 patients of the Hp-negative group and 12（52%） of the 23 patients of the Hp-positive group experienced new coronary stenotic lesion and in-stent restenosis.There was no statistical significance.CONCLUSION：There was no definite relationship between Hp infection and CAD.Further studies are needed in this area.

关 键 词：幽门螺杆菌 冠状动脉疾病 

分 类 号：R541.4[医药卫生—心血管疾病]