免疫抑制剂SIPI-96-1014的分离和鉴别  

SIPI-96-1014, an immunosupperssant: isolation and identificaton

作　　者：姜健[1] 龚炳永[1] 郝伟月[1] 谢家政 

机构地区：[1]上海医药工业研究院,上海200040

出　　处：《中国抗生素杂志》2000年第1期5-8,73,共5页Chinese Journal of Antibiotics

摘　　要：在应用酵母突变株模型筛选免疫抑制剂过程中,筛选出一阳性菌株SIPI961014。经过发酵提取,分离和纯化,从其菌丝体中分离出一个活性化合物SIPI961014。通过对其理化性质等光谱数据的分析,确定其结构与化合物邻羟基乙酰苯胺一致。生物学活性研究表明,其对酵母野生株和突变株具有一定的抑制活性,详细的免疫抑制活性有待于进一步研究。As part of a program aimed at discovering novel immunosuppressive agents, we have isolated a Streptomyces hygroscopicus No.1014. One active component, SIPI 96 1041 was isolated from the culture broth and it showed strong inhibitory effect on the test organisms Saccharomyces cerevisiae (Wild type) and Saccharomyces cerevisiae (Mutant type). Based on the spectral data and physico chemical properties of SIPI 96 1014, it has been identified as O hydroxyacetanilide. The details about immuno pharmacological profile of this immunosuppressive agent were under investigation.

关 键 词：免疫抑制剂 分离 鉴别 SIPI-96-1014 

分 类 号：R979.5[医药卫生—药品]