茎点霉299产生的免疫抑制剂I.SIPI-299-B、299-O的研究  

Immunosuppressants isolated from a Phoma sp. 299 Ⅰ. Studies on compounds SIPI-299-B and 299-O

作　　者：张礼萍[1] 龚炳永[1] 郝伟月[1] 

机构地区：[1]上海医药工业研究院,上海200040

出　　处：《中国抗生素杂志》2000年第1期9-11,67,共4页Chinese Journal of Antibiotics

摘　　要：应用筛选免疫抑制剂的酵母模型,从一真菌茎点霉299中分离得到两个活性化合物299B和299O。经波谱分析(UV、EIMS、FABMS、1HNMR、13CNMRDEPT、1H1HCOSY、HMQC),证实它们均为大环内酯化合物,分别与VerrucrinA和B相同。两个化合物均有强的免疫抑制活性。In the course of screening for immunosuppressants with a simple Saccharomyces model, a fungus Phoma sp. 299 was found to be a positive strain. Two active compounds 299 B and 299 O were isolated from it. They are classified to macrolide family. Their structures are identified as verrucarin A and B respec tively based on their spectroscopic data.

关 键 词：免疫抑制剂 茎点霉 SIPI-299 清酒酵母模型 

分 类 号：R979.5[医药卫生—药品]