Altered regional homogeneity in spontaneous cluster headache attacks： a resting-state functional magnetic resonance imaging study  

作　　者：Qiu En-chao Yu Sheng-yuan Liu Ruo-zhuo Wang Yan Ma Lin Tian Li-xia 

机构地区：[1]Chinese Peoples Liberat Army Gen Hosp, Dept Neurol, Beijing 100853, Peoples R China [2]Chinese Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing 100853, Peoples R China [3]Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Neurol, Beijing 100037, Peoples R China [4]Beijing Jiaotong Univ, Sch Comp & Informat Technol, Beijing 100044, Peoples R China

出　　处：《Chinese Medical Journal》2012年第4期705-709,共5页中华医学杂志（英文版）

基　　金：This work was supported by grants from the National Natural Science Foundation of China （No.30970417 and 81171058）.

摘　　要：Background Functional neuroimaging study has opened an avenue for exploring the pathophysiology of cluster headache （CH）.The aim of our study was to assess the changes in brain activity in CH patients by the regional homogeneity method using resting-state functional magnetic resonance imaging technique.Methods The functional magnetic resonance imaging scans were obtained for 12 male CH patients with spontaneous right-sided headache attacks during “in attack” and “out of attack” periods and 12 age- and sex-matched normal controls.The data were analyzed to detect the altered brain activity by the regional homogeneity method using statistical parametric mapping software.Results Altered regional homogeneity was detected in the anterior cingulate cortex,the posterior cingulate cortex,the prefrontal cortex,insular cortex,and other brain regions involved in pain processing and modulation among different groups.Conclusion It is referred that these brain regions with altered regional homogeneity might be related to the pain processing and modulation of CH.：Background Functional neuroimaging study has opened an avenue for exploring the pathophysiology of cluster headache （CH）.The aim of our study was to assess the changes in brain activity in CH patients by the regional homogeneity method using resting-state functional magnetic resonance imaging technique.Methods The functional magnetic resonance imaging scans were obtained for 12 male CH patients with spontaneous right-sided headache attacks during “in attack” and “out of attack” periods and 12 age- and sex-matched normal controls.The data were analyzed to detect the altered brain activity by the regional homogeneity method using statistical parametric mapping software.Results Altered regional homogeneity was detected in the anterior cingulate cortex,the posterior cingulate cortex,the prefrontal cortex,insular cortex,and other brain regions involved in pain processing and modulation among different groups.Conclusion It is referred that these brain regions with altered regional homogeneity might be related to the pain processing and modulation of CH.

关 键 词：cluster headache functional magnetic resonance imaging resting state  regional homogeneity 

分 类 号：Q426[生物学—神经生物学] P642.22[生物学—生理学]