耐甲氧西林表皮葡萄球菌医院感染危险因素分析  

Risk factors of nosocomial infection caused by methicillin resistant staphylococcus aureus

作　　者：王爱 康京花 周炯 赵丽珍 冷晓梅 马小军[1] 刘海燕[2] 

机构地区：[1]中国医学科学院北京协和医院医院感染管理办公室,100032 [2]装甲兵工程学院门诊部

出　　处：《中国急救复苏与灾害医学杂志》2012年第2期156-159,共4页China Journal of Emergency Resuscitation and Disaster Medicine

摘　　要：目的调查某院耐甲氧西林表皮葡萄球菌（MRSE）医院感染特点，并探讨其发生的危险因素，为抗菌药物的合理应用及医院感染控制提供帮助。方法对本院2009年1月。2010年12月送检标本中检出耐甲氧西林表皮葡萄球菌（MRSE）的住院患者进行统计，对其进行回顾性分析。结果184例病例，男性104例，女性80例；96例存在医院感染，88例为细菌定植。感染组与非感染组在性别、有否气管插管、动静脉置管、感染前三个月有否应用抗菌药物、粒细胞缺乏、慢性肾功能不全、恶性肿瘤、心血管疾病、慢性支气管炎、血液病、重大手术、肝硬化、免疫性疾病差异无统计学意义（P〉0．05），而在有否留置导尿、一年内有否应用免疫抑制剂、激素治疗、糖尿病、老龄、颅脑疾病差异有统计学意义（P〈0．05）。结论留置导尿、免疫抑制剂应用、激素治疗、糖尿病、老龄、颅脑疾病为MRSE感染的危险因素。Objective To investigate the risk factors of nosocomial infection caused by methicillin resistant Staphylococcus aurens （MRSE）. Methods The clinical data of 184 patients admitted 2009 - 2011, 104 males and 84 females, aged （48.3 ± 22.2）, from whose specimens MRSE were detected, were analyzed retrospectively. Results 96 of the 184 patients were diagnosed as with nosocomial infection of MRSE and 88 of the 96 cases were diagnosed as infection with colonizers. The infection rates of MRSE were not significantly different in sex, tracheal intubation, arteriovenous catheterization, use of antibiotics within the 3 months before the infection, agranulocytosis, chronic renal insufficiency, malignant tumor, cardiovascular diseases, chronic bronchitis, blood diseases, major operation, cirrhosis, and immune diseases between the MRSE infection group and non-infection group （all P〉0.05）. However, the MRSE infection rates of those older, with indwelling urinary catheter, treated with immunosuppressant drug or steroid within one year, with diabetes or neurologic disease were all significantly higher than those without these factors （all P〈0.05）. Conclusion The risk factors for MRSE infection include g urethral catheterization, immunosuppressant drug application, steroid treatment, diabetes, senior age and neurologic disease.

关 键 词：耐甲氧西林表皮葡萄球菌 医院感染 危险因素 

分 类 号：R631[医药卫生—外科学]