^(15)N-甘氨酸、^(13)C-棕榈酸体内示踪在肠功能监测中的应用  

~15N-Gly and ~13C-Palmitic Acid Used as Tracers to Measure Intestinal Absorption.

作　　者：刘坚[1] 王彬[2] 吴肇汉[3] 

机构地区：[1]浙江省杭州市第一人民医院外科,310006 [2]浙江医科大学附属第二医院外科,310006 [3]上海医科大学附属中山医院外科,200032

出　　处：《外科理论与实践》2000年第1期13-16,共4页Journal of Surgery Concepts & Practice

摘　　要：研究应用稳定同位素^（１５）Ｎ－甘氨酸和^（１３）Ｃ－棕榈酸示踪测定全小肠切除术后患儿的肠吸收功能。方法：以 一例全小肠切除术后患儿作自身对照，两名健康儿童作正常对照，定期用~１５Ｎ－甘氨酸示踪试验和~１３Ｃ－棕榈酸呼气 试验来检测患儿残留消化道对氨基酸和脂肪酸的代偿吸收功能。结果：患儿在术后１５月及２４月对氨基酸的相对 吸收率分别为５０％和５２％，吸收高峰时间均在２．５～３．５ｈ。对脂肪酸的相对吸收率则分别为５７％和７５％，吸收高峰 时间在３．５～４．５ｈ。结论：用稳定同位素法测定肠吸收功能不仅安全、灵敏、特异性好，而且还反映肠吸收高峰时 间。根据本研究结果推断，结肠可能代偿吸收营养要素。To study the use of nonradioactive isotope labeled substracts ~15N-Gly and ~13C-Palmitic Acid as tracers in measuring the adaptive absorptive function in a child having undergone total small bowel resection. Methods: ~15N-Gly trace test and ~13C-Palmitic Acid breath test were used in the patient and 2 healthy children as controls. Using the study was carried out once in the controls and at the 15th and 24th months postoperatively in the patient. Results: The relative absorption rate of ~15N-Gly was 50% and 52% at the 15th and 24th months, and the absorption reached its peak value between 2.5 and 3.5 hours. The relative absorption rate of ~13C-Palmitic Acid reached 57% at the 15th month and was further increased to 75% at the 24th month. The absorption reached the peak value between 3.5 and 4.5 hours. Conclusions: The use of stable isotopes to measure intestinal absorption rate is not only an non-invasive, sensitive and specific method of study, but could also provide information regarding the peak absorption time. From the results obtained in the present study, it is speculated that the colon exercises a compensatory absorption role to cope with the total absence of the small bowel.

关 键 词：全小肠切除 肠吸收 儿童 同位素示踪剂 

分 类 号：R459.3[医药卫生—治疗学]