姜黄素长期毒性试验  

Long-period Virulent Test of Curcumin

作　　者：沃兴德[1] 洪行球[1] 高承贤[1] 金明敏[1] 李万里[1] 丁志山[1] 唐利华[1] 

机构地区：[1]浙江中医学院分子医学研究所,杭州310009

出　　处：《浙江中医学院学报》2000年第1期61-65,共5页Journal of Zhejiang College of Traditional Chinese Medicine

基　　金：国家中医药管理局科研基金!92 B0 49

摘　　要：在确定姜黄素无急性毒性作用的前提下 ,我们用姜黄素进行长期毒性试验 ,分高、低 2个剂量组 ,连续给药 80天 ,部分动物停药后继续观察 2周。经一般状况观察 ,10项血液生化指标 ,8项血液学指标 ,大体解剖及病理学观察。结果姜黄素高剂量组〔5 0 0 mg/ (kg· d)〕、低剂量组〔10 0 mg/ (kg·d)〕各项指标与正常对照组比较 ,均无显著差异 ,说明姜黄素在上述剂量下连续服用 80天是安全的。Under the prerequisite that curcumin had no acute virulent function,we made a long-period virulent test of curcumin,two groups of animals with high and low dosages were formed,and continuously given drugs for 80 days,then we observed them for 2 weeks.The observed items were 10 biochemical indexes of blood,8 hematological indexes,general dissection and pathology.It turned out that all the quotas of the group with high dosage of curcumin [50mg/(kg·d)]and the one with low dosage[100mg/(kg·d)]had no clear difference from that of control group,therefore it's concluded that curcumin was safe if taken 80 days continuously under the dosages above.

关 键 词：姜黄素 SD大鼠 长期毒性试验 中药 

分 类 号：R285.1[医药卫生—中药学] R285.5[医药卫生—中医学]