金鸡纳碱衍生物修饰的负载钌-铑双金属催化剂催化芳香酮不对称加氢  

Asymmetric Hydrogenation of Aromatic Ketones Catalyzed by Cinchona-and PPh_3-Modified RuRh/γ-Al_2O_3

作　　者：蒋和雁[1] 陈华[2] 

机构地区：[1]重庆工商大学药物化学与化学生物学研究中心重庆高校催化理论与应用技术市级重点实验室,重庆400067 [2]四川大学化学学院有机金属络合催化研究所绿色化学及技术教育部重点实验室,成都610064

出　　处：《化学学报》2012年第3期297-302,共6页Acta Chimica Sinica

基　　金：重庆市科委自然科学基金计划(No.CSTC;2011BA5025);重庆市教委自然科学基金(No.KJ100701);重庆工商大学科研启动基金(No.2010-56-14);重庆市科技创新团队(No.KJTD201020)资助项目~~

摘　　要：以金鸡纳碱衍生物作为手性修饰剂,研究了三苯基膦稳定的1.0%Ru+0.2%Rh/γ-Al2O3催化剂催化芳香酮多相不对称加氢,考察了修饰剂种类及浓度、碱添加剂种类及浓度、溶剂、氢气压力等因素对不对称加氢反应的影响.结果表明,金鸡纳碱衍生物对1.0%Ru+0.2%Rh/γ-Al2O3-tpp催化剂具有较好的修饰作用,在优化反应条件下苯乙酮加氢反应的对映选择性高达84%.The asymmetric hydrogenation of aromatic ketones catalyzed by cinchona- and PPh3-modified 1.0% Ru＋0.2% Rh/y-Al2O3 was studied. The effects of different modifiers, modifier concentration, different base additives, base additive concentration, solvents, and hydrogen pressure on the asymmetric hydro- genation of aromatic ketones were investigated in detail. The results showed that cinchona alkaloids had good modification effects on the 1.0% Ru＋0.2% Rh/γ-Al2O3-tpp catalyst. Under the optimum conditions, the hydrogenation enantioselectivity of acetophenone was up to 84%.

关 键 词：钌 铑 金鸡纳碱 芳香酮 不对称加氢 

分 类 号：O643.32[理学—物理化学]