黄芩苷磷脂复合物单侧鼻腔给药脑靶向性研究  

Brain Targeting of Baicalin-Phospholipid Solution after Unilateral Nasal Administration

作　　者：李楠[1,2] 叶英杰[1] 杨明[3] 蒋学华[2] 

机构地区：[1]成都中医药大学药学院,成都611137 [2]四川大学华西药学院,成都610041 [3]江西中医学院中药现代制剂教育部重点实验室,南昌330004

出　　处：《中国药学杂志》2012年第4期283-286,共4页Chinese Pharmaceutical Journal

摘　　要：目的研究黄芩苷磷脂复合物溶液单侧鼻腔给药后黄芩苷在大鼠体内血浆与左、右嗅球,左、右脑及小脑中的药物分布,并评价其脑靶向性。方法大鼠静注黄芩苷磷脂复合物溶液,单侧(左侧)鼻腔给予黄芩苷磷脂复合物溶液后,采用HPLC分别测定血浆中及各脑组织中黄芩苷的浓度。结果药物经左侧鼻腔给药后,最高药物浓度出现在左嗅球,其次为右嗅球,接下来分别为左脑、右脑及小脑。嗅区转移率分别为100%、100%、75.06%、62.39%、65.11%。结论黄芩磷脂复合物经鼻腔给药后,黄芩苷可由"鼻-脑"通路实现药物的脑靶向分布。OBJECTIVE To investigate the distribution of baicalin-phospholipid solution after unilateral nasal administration in rat blood and left olfactory, right olfactory bulb, left brain, right brain, and the cerebellum, and to evaluate its brain targeting effect. METHODS After intravenous and unilateral nasal administration of baicalin-phospholipid solution, the concentrations of baicalin-phospholipid in the plasma and the brain tissues of the rats were determined by HPLC. RESULTS After administration by left nasal cavity, the drug concentration was maximum in the left olfactory bulb, followed by the right olfactory bulb, left brain, right brain, and fi- nally the eerebellum. The olfactory propotion was 100% ,100% ,75.06% ,62. 39% and 65. 11% ,respectively. CONCLUSION Ba- iealin can distribute into brain by ＂nose-brain＂ transport pathway after intranasal administration of baicalin-phospholipid.

关 键 词：黄芩苷磷脂复合物 单侧鼻腔给药 脑靶向 

分 类 号：R944[医药卫生—药剂学]