石菖蒲抗癫痫作用及其机制的研究进展  

Progress in research of antiepileptic effect of acori tatarinowii rhizoma and the mechanism

作　　者：石瑜[1] 邓艳春[1] 

机构地区：[1]第四军医大学西京医院神经内科,西安710032

出　　处：《中国新药杂志》2012年第4期385-389,共5页Chinese Journal of New Drugs

摘　　要：癫痫是最常见的神经系统疾病之一,发病率逐年增加,目前其主要治疗手段是药物治疗,但是效果有限。石菖蒲具有开心窍、益心智、安心神等功效,是祖国医学治疗癫痫症的常用味药;石菖蒲的多种提取物及其有效成分α-细辛醚具有抗癫痫作用,在癫痫的多种发病机制中发挥了降低神经兴奋性、保护神经元等作用。同时,石菖蒲对神经系统还具有兴奋性和抑制性双向调节作用。本文主要综述了目前癫痫发病机制的研究进展,在此基础上探讨中药石菖蒲的抗癫痫作用及其可能的作用靶点,论述其发展为辅助抗癫痫药物的可能性。Epilepsy is one of the most common neurological disorders.The worldwide incidence of epilepsy gradually increases with years.Currently,as the main treatment method to epilepsy,the curative effect of drug therapy is limited.Acori tatarinowii rhizoma,a traditional Chinese medicine,has various beneficial effects inducing resuscitation,promoting mentality and calming mind.The extracts from acori tatarinowii rhizoma and its active component（α-asarone） have an antiepileptic and neuroprotective effect.In the central nervous system,it is proved to regulate cerebral function through balance of excitability and inhibition.How to rationally exploit acori tatarinowii rhizoma and transform it into an effective drug as an adjuvant therapy of epilepsy is an aim of investigators＇ current research.

关 键 词：癫痫 石菖蒲 Α-细辛醚 

分 类 号：R969.1[医药卫生—药理学] R979.1[医药卫生—药学]