尼美舒利对照布洛芬治疗儿童发热的临床评价  

Clinical comparison of the effects of nimesulide and ibuprofen on fever in children

作　　者：周俊翔[1,2] 余文韬[1] 吴斌[1,2] 杨姝[2] 唐尧[1] 

机构地区：[1]四川大学华西医院药剂科 [2]四川大学华西药学院,成都610041

出　　处：《中国新药杂志》2012年第4期451-457,共7页Chinese Journal of New Drugs

摘　　要：目的:评价尼美舒利和布洛芬治疗儿童发热的疗效和安全性。方法:计算机检索Pubmed,Cochrane图书馆、CNKI,CBM,维普、万方6个数据库,采用Cochrane系统评价方法对纳入的随机对照试验(RCTs)进行方法学质量评价,并用Revman 5.0.0软件进行Meta分析。结果:共纳入24项RCTs,共计3 773例患者。Meta分析结果显示,尼美舒利与布洛芬相比,治疗1 h(RR=1.34,95%CI:[1.18,1.52],P<0.000 01)和6 h(RR=1.26,95%CI:[1.15,1.37],P<0.000 01)后的疗效差异均有统计学意义,安全性方面二者在恶心、呕吐(RR=0.23,95%CI:[0.13,0.40],P<0.000 01)以及嗜睡(RR=6.43,95%CI:[1.19,34.65],P=0.03)发生率上差异有统计学意义。结论:尼美舒利治疗儿童发热疗效优于布洛芬,安全性还有待进一步研究。Objective： To evaluate the effectiveness and safety of nimesulide and ibuprofen in children with fever.Methods： Six databases were searched,including Pubmed,Cochrane Library,CNKI,CBM,WanFang and VIP.The quality of RCTs was assessed according to the methods of Cochrane systematic review.Meta-analysis was performed using Revman 5.0.0 software.Results： A total of 24 RCTs involving 3773 patients were included.The result of Meta analysis showed that nimesulide was significantly superior to ibuprofen in 1h effective rate（RR=1.34,95% CI：1.18~1.52,P0.00001） and in 6h effective rate（RR=1.26,95% CI：1.15~1.37,P0.00001）.In aspect of safety,there were statistically significant differences between them in nausea and vomiting（RR=0.23,95% CI：0.13~0.40,P0.00001）,and in somnolence（RR=6.43,95% CI：1.19~34.65,P=0.03）.Conclusion： The antipyretic effect of nimesulide is better than that of ibuprofen in children,and the safety of nimesulide needs investigation.

关 键 词：尼美舒利 布洛芬 发热 儿童 系统评价 META分析 

分 类 号：R971.1[医药卫生—药品]