老年男性2型糖尿病患者瘦素水平与骨密度关系的研究  

Clinical features and follow-up data of 436 cases of undifferentiated spondyloarthropathies

作　　者：徐双迎[1] 汪娅[1] 吴红艳[1] 

机构地区：[1]长江大学附属第一医院,湖北省荆州市434000

出　　处：《实用医学杂志》2012年第4期589-591,共3页The Journal of Practical Medicine

摘　　要：目的:探讨老年男性2型糖尿病(T2DM)患者血浆瘦素水平与骨密度(BMD)的关系。方法:89例老年男性T2DM患者按照指骨BMD分为3组,骨质疏松(A)组32例、低骨量(B)组36例及骨量正常(C)组21例,分别比较各组血浆瘦素、指骨BMD、BMI、血浆甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、HbA1c及骨碱性磷酸酶(BALP)水平。结果:相关性研究显示,老年男性T2DM患者血浆瘦素水平与BMI、指骨BMD呈正相关(r=0.32,r=0.43,P<0.05);多元逐步回归分析表明,瘦素与BMI分别是影响指骨BMD的独立相关因素(r2=0.331,P<0.05)。结论:老年男性T2DM患者血浆瘦素水平与指骨BMD呈正相关,瘦素为影响指骨BMD的独立相关因素,瘦素参与调节骨代谢过程,可能为老年男性T2DM患者骨质疏松症发病的独立危险因素之一。Objective To explore the clinical features and the developmental rules of undifferentiated spondyloarthropathies（uSpA）.Methods The clinical,laboratory,and follow-up data in 436 patients with uSpA in the First Affiliated Hospital of Sun Yat-sen University from Jan 2000 to June 2010 were collected and analyzed.Results Among the 436 patients with uSpA,there were 284 male and 152 females,aged from 13 to 54（25±7） years,and the course of disease was（31±10.7） months.The chief symptoms were lumbar pain（55.2%） and enthesitis（47.7%）.After the follow-up,the symptoms were disappeared in 74 patients（17.0%）,remained to be uSpA in 129 patients,and developed to other diseases in 233 patients（including 192 cases with spondyloarthropathy in other differentiated subtype and 41 cases with other connective tissue disease）.Conclusion USpA is a group of diseases with complex clinical characteristics.Some patients can develop to ankylosing spondylitis,psoriatic arthritis,or enteropathic arthropathy.So the uSpA patients should be observe and followed-up tightly.

关 键 词：糖尿病 2型 瘦素 老年男性 骨密度 

分 类 号：R580[医药卫生—内分泌]