应用斑点追踪成像技术评价GHb异常糖尿病患者的左室舒张功能  

The value of heart-type fatty acid binding protein qualitative detection for diagnosis of early acute myocardial infarction

作　　者：戴敏[1] 钱大钧[1] 刘晓宇[1] 曹黎君[1] 谈君[1] 

机构地区：[1]南京医科大学附属无锡人民医院心功能科,214023

出　　处：《实用医学杂志》2012年第4期591-593,共3页The Journal of Practical Medicine

摘　　要：目的:探讨斑点追踪成像技术评价糖化血红蛋白(glycosylated hemoglobin,GHb)异常糖尿病患者左室舒张功能的临床价值。方法:选取38例GHb异常糖尿病患者、正常对照组32例,在左室心尖位长轴图像上测量基底段、中间段、心尖段各心肌节段纵向应变率(SrL)的舒张早期峰值(E’)、舒张晚期峰值(A’)和E’/A’的平均值,在左室短轴二尖瓣水平、乳头肌水平、心尖水平测量各心肌节段圆周应变率(SrC)和径向应变率(SrR)的E’、A’和E’/A’的平均值,同时测量左心常规超声指标。结果:与对照组相比,GHb异常糖尿病患者SrL的E’降低、A’升高以及E’/A’降低,差异有统计学意义(P<0.05);GHb异常糖尿病患者SrC的E’及SrC、SrR的E’/A’降低,SrC、SrR的A’升高,差异有统计学意义(P<0.05);两组间左心常规超声指标差异无统计学意义(P>0.05)。结论:GHb异常糖尿病患者左室舒张功能受损的早期改变是SrL、SrC的E’及E’/A’降低,SrL、SrC及SrR的A’升高,同时SrL、SrC及SrR的运动规律消失。Objective To evaluate the efficacy of blood H-FABP in the diagnosis of early AMI.Methods We selected 104 patients with suspected AMI at admission within 3 hours after onset of chest pain,The blood HFABP was assayed by the gold immunochromatography,then compared with blood cTnI,CK-MB and MYO in sensitivity,specificity.Results Among the 104 recruited patients,50 cases had a find diagnosis of AMI,and 54 cases were excluded.The results displayed the sensitivity of H-FABP,cTnI,CK-MB and MYO in diagnosis of AMI were 88.00%、68.00%、64.00% and 84.00% respectively,and the specificity were 90.74%、87.04%、85.19% and 70.37% respectively.In sensitivity,H-FABP was significantly higher than cTnI and CK-MB（P 0.05 for all）,but there was no significant difference from MYO（P 0.05）.in specificity,H-FABP was significantly higher MYO（P 0.05）,while no significant difference from cTnI or CK-MB（P 0.05 for all）.In four kinds of myocardial injury markers,H-FABP has the highest accurate diagnosis index.Conclusion H-FABP has feasibility in early diagnose of AMI,qualitative detection of H-FABP was rapid,simple,high sensitivity and specificity,and deserves to be applied broadly.

关 键 词：超声心动描记术 斑点追踪成像 糖尿病 糖化血红蛋白 左室舒张功能 

分 类 号：R587.1[医药卫生—内分泌] R542.2[医药卫生—内科学]