2-取代酰氨基-5-去氢枞基-1,3,4-噻二唑衍生物的合成及杀菌活性  

Syntheses and Fungicidal Activities of 2-Sustituted acylamino-5dehydroabietyl-1,3,4-thiadiazole Derivatives

作　　者：莫启进[1] 段文贵[1] 马献力[1,2] 林桂汕[1] 许雪棠[1] 岑波[1] 

机构地区：[1]广西大学化学化工学院,桂林541004 [2]桂林医学院药学院,桂林541004

出　　处：《化学通报》2012年第2期160-165,共6页Chemistry

基　　金：国家自然科学基金项目(31060100);广西自然科学基金重点项目(2010GXNSFD013013);广西研究生教育创新计划项目(105931001007)资助

摘　　要：为了寻找具有更高生物活性的新颖先导化合物,本文以去氢枞酸为原料,设计并合成了11个具有1,3,4-噻二唑骨架的新型去氢枞酸衍生物,通过1H NMR、13C NMR、IR、EI-MS和元素分析确认了目标产物的结构。初步的生物活性测试结果表明,大部分化合物具有一定的杀菌活性,其中,化合物2在浓度为50mg/L时对番茄早疫病菌的抑制率达88.9%。In order to search for novel leading compounds, eleven novel dehydroabietic acid derivatives bearing 1,3,4-thiadiazole moieties were designed and synthesized by using dehydroabietic acid as starting material. All the titled compounds were analyzed and characterized by means of IH NMR, 13C NMR, IR, EI-MS, and elemental analysis. The preliminary bioassay showed that most of the titled compounds exhibited a certain fungicidal activity, in which compound 2 had inhibition rate of 88.9% against Alternaria solani at the concentration of 50mg/L.

关 键 词：去氢枞酸 1 3 4-噻二唑 酰胺 杀菌活性 

分 类 号：TQ455.4[化学工程—农药化工]