33例骨髓增生异常综合征的染色体核型分析  

Chromosomal karyotype analysis of 33 cases of myelodysplastic syndrome

作　　者：何涛[1] 

机构地区：[1]安徽医科大学第一附属医院血液内科,合肥230022

出　　处：《安徽医学》2012年第1期21-23,共3页Anhui Medical Journal

摘　　要：目的分析染色体核型异常在骨髓增生异常综合征(MDS)诊断、预后评估中的价值。方法对33例MDS患者按常规行骨髓穿刺,进行形态学检查,同时对患者骨髓细胞进行染色体培养,采用直接法、短期培养法和RHG显带技术制备染色体,进行核型分析。结果 33例MDS患者中,染色体核型异常者15例,异常核型检出率45.4%,其中MDS-RA 1例占3%,MDS-RARS 1例占3%,MDS-RCMD 4例占12.1%,MDS-RAEB1 6例占18.2%,MDS-RAEB2 3例占9.1%。MDS-RAEB1、2较RA、RARS、RCMD检测到更高的异常核型比例。结论 MDS的染色体核型异常,各型之间差异较大,染色体核型分析对MDS的诊断、分型及预后评估有重要价值。Objective To analyze the value of chromosome abnormal karyotype in diagnosis and prognosis of myelodysplastic syndrome（MDS）.Methods 33 cases of MDS patients were carried out routine bone marrow aspiration and to be morphologically checked,while the bone marrow cells of the patients were chromosomally cultured,using direct method,brief culture of cells and R-banding techniques,then karyotype analysis was performed.Results Among 33 cases of MDS patients,15 cases were found with chromosomal abnormal karyotype,the abnormal karyotype detection rate was 45.4%,in which there were 1 case（3%） of MDS-RA,1 case（3%） of MDS-RARS,4 cases（12.1%） of MDS-RCMD,6 cases（18.2%） of MDS-RAEB1,and 3 cases（9.1%） of MDS-RAEB2.The abnormal karyotype detection rate in MDS-RAEB1 and MDS-RAEB2 was much higher than that in RA,RARS,RCMD.Conclusion Karyotype abnormalities are the larger differences between various types of karyotype analysis of MDS,so karyotype analysis is very useful for diagnosis,typing and prognosis evaluation in MDS.

关 键 词：骨髓增生异常综合征 染色体异常核型 诊断预后 

分 类 号：R551.3[医药卫生—血液循环系统疾病]