头孢哌酮钠与利巴韦林注射液在3种输液中配伍的稳定性研究  

Compatibility and Stability of Cefoprazone Sodium with Ribavirin Injection in Three Infussion Solutions

作　　者：李革晖 苏佳 黄晶[2] 

机构地区：[1]广西南溪山医院,桂林541002 [2]桂林医学院

出　　处：《中国药师》2000年第1期33-35,共3页China Pharmacist

摘　　要：目的:研究在不同温度(4℃,25℃,37℃)条件下头孢哌酮钠和利巴韦林注射液在0.9％氯化钠注射液,葡萄糖氯化钠注射液,10％葡萄糖注射液3种输液中的配伍稳定性。方法:将头孢哌酮钠,利巴韦林注射液加入3种不同的输液中,配成浓度分别为2mg·ml^(-1),1mg·ml^(-1)的混合液,放置不同温度下(4℃,25℃,37℃),用紫外分光光度法,测定配伍后不同时间混合液中两药的浓度,同时检查混合液pH值、外观及不溶性微粒变化。结果:二者混合液放置在4℃,8h,微粒数超过规定标准;放置在25℃,37℃下在8h内溶液均澄明,pH值、含量没有明显变化。结论:头孢哌酮钠和利巴韦林注射液在3种输液中配伍8h内稳定,在低温下,不溶性微粒有增多的可能。Aim: To study compatibility and stability of cefoperazone sodium with ribavirin injection in 0.9 % sodium chloride injection, 5 % glucose and sodium chloride injection, and 10 % glucose injection in three different temperatures(4℃, 25 ℃ , 37℃). Method: Admixture of cefoperazone 1 g, ribavirin(l mg/ml) 5 mg and 500 ml of 3 different infusion solutions were prepared and stored at 4℃ , 25℃, 37℃ . UV spectrophotometry was used to determine cefoperazone and rivavirin concentrations, pH and visual variation, the number of particle were also detected at different time during the period of study. Results: The number of particle is higher than the standard of China Pharmacopoeia at 4 1C after 8 h; the concentrations, pH, color and visual variation and the number of particulate did not change and no precipitate and gas were produces at 25℃ , 37℃ after 8 h. Conclusion: The compatibility of cefoperazone with ribavirin injection in three infussion solutions are stable within 8 h, but the number of particulate may be increased at the lower temperature.

关 键 词：头孢哌酮钠 利巴韦林 输液 配伍 稳定性 

分 类 号：R978.11[医药卫生—药品] R927.11[医药卫生—药学]