基于高分辨率MRI的中国正常成人颅腔体积测量  

Measurement of intracranial wolume of healthy Han Chinese hased on high resolution MRI

作　　者：贾科峰[1] 于长路[1] 张翔[1] 陈楠[2] 韩丹[3] 李坤成[2] 

机构地区：[1]天津市第三中心医院放射科,天津300170 [2]首都医科大学宣武医院放射科,天津300170 [3]昆明医学院第一附属医院影像中心,天津300170

出　　处：《实用放射学杂志》2012年第2期167-169,共3页Journal of Practical Radiology

基　　金：国家科委“八六三”计划资助项目（2006AA022391）;科技部“九七三”资助项目（2005CB522800、2004CB318101）;国家自然科学基金资助项目（3062i004、30870697）.

摘　　要：目的研究中国汉族正常成人颅腔体积的大小分布，为建立“中同标准脑”提供颅腔体积测量数据。方法采用全国l6家医院多中心l临床研究形式，选取18-70岁健康志愿者300名，其中男l50名。女l50名，按照年龄18-30、3l-40、4l-50、51-60、6l-70岁进行分组，分别定义为A、B、C、D、E组。所有受试者均行三维磁化强度预备梯度同波序列T2W1采集图像，并对不同性别和年龄段的颅腔体积分别进行方差分析。结果女性颅腔体积为（2429l24．385±255532．028）mm3．男性为（2696425．759±269059．771）mill。，颅腔体积在性别上差异有统计学意义（F值为79．284．P值为0．000），女性的颅腔体积较男性的小。A、B、C、D、E组颅腔体积分别为（2617133．937±300444．676）mm3、（2569966．953±315781．536）mm3、（2557420．101±326607．557）mm3、（2565465．432±243349．1l6）mm3、（2516984．969±283908．89）mm3。5组间颅腔体积差异无统计学意义（F值为1．883，P值为0．474）。结论高分辨率MRI能提供较为精确的脑结构图像和测量数据，本研究提供r中国汉族正常成人颅腔体积的参考值范嗣，为建立“中国标准脑”提供了科学数据。Objective To investigate the intraeranial volume of healthy Han Chinese adults so that to provide intracranial volume data for the establishment of ＂Chinese standardized brain＂. Methods In the multi-center, 300 heahhy volunteers of both genders （male 150, and female 150} , aged from 18 70 years, were chosen from 16 teaching hospitals. They were divided into five groups （A, B, C, D, E） by theage, namely 18-30 group, 31-40 group, 41-50 group, 51 60 groupand 61 70 group. Allof the vol- unteers received head MRI scan （T1WI three dimensional magnetization prepared rapid acquisition gradient echo sequences, T2WI 3I） MPRAGEl. Sta＇dstical data of intracraniai volume of different groups （gender or agel were treated by ANOVA. Results The value of intracranial volume of female volunteers was （2 429 124. 385~ 255 532. 028} mm3, and it was （2 696 425. 759± 269 059. 771 ） mma of male volunteers. The difference hetween female and male groups in intracranial volume was significant （F was 79. 284, P was 0. 000）, and the value of intracranial volume o[ female volunteers was smaller than it of male ones. The values of in- tracranial volume of group A, B, C, D and E were （2 617 137,. 937~_300 444. 676） mma, （2 569 966. 953＋--315 781. 536） mm：~ , （2 557 420. 101--＋_326 607.557） mma, （2 565 465. 432±243 349.116） mm3, （2 516 984. 969±283 908.89） mm3, respectively, and the difference among these five groups in intracranial volume was insignificant （F was 1. 883, P was 0. 474）. Conclusion High resolution MR imaging can provide more precise images and data of intracranial volume of healthy adults. This study offers the range of value of intracranial volume of healthy for the establishment of ＂Chinese standardized brain＂.

关 键 词：颅腔体积 磁共振成像 器官测量 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学] R445.2[医药卫生—基础医学]