AFP、uE3、freeβ-HCG联检对孕中期妇女胎儿缺陷筛查有效性及影响因素分析  

Effectiveness and Influence Factors Analysis of Combined Detection of AFP,uE3 and freeβ-HCG on Fetal Defects Screening in Pregnant Women During Second Trimester

作　　者：林松[1] 涂文瑞[1] 

机构地区：[1]福建中医药大学附属三明市中西医结合医院,福建三明350001

出　　处：《标记免疫分析与临床》2012年第1期11-13,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨孕中期妇女检查AFP、uE3、freeβ-HCG三项对筛查胎儿缺陷的意义,并探讨影响风险值的相关因素。方法用化学发光法,采用美国Beckman Coulter Access2全自动化学发光仪测定1633例在我院建卡产检的35周岁以下孕中期(16～20周+5天)孕妇血清中AFP、uE3、freeβ-HCG的浓度,并使用厂家提供的风险计算软件评估风险。结果唐氏综合症、18-三体综合症和神经管缺陷高风险发生率分别为:1.7%、0.5%、3.5%;重度溶血标本与孕周差异对高风险筛查有一定影响。结论产前筛查应该作为孕妇产科常规检查之一[1],重度溶血,有可能对风险预测值有影响,建议工作中采用新鲜无溶血标本及时检测。Objective To explore the clinical value and influence factors of combined detection of AFP, uE3, freeβ-HCG on fetal defects screening in pregnant women during second trimester. Methods The serum levels of AFP, uE3, free -βHCG in 1633 cases of pregnant women under 35 years old during second trimester were detected by using Beckman Coulter Access2 automated chemiluminescence, and risk assessment was carried outby manufacturers calculation software. Results The high risk incidence rates of Down syndrome, trisomy 18 syndrome and neural tube defects were 1.7% , 0.5% and 3.5% respectively. The severe hemolysis and gesta- tional age differences had certain effects on the high risk screening. Conclusion The prenatal screening should be as routine examination for pregnant women. The severe hemolysis has potential effect in risk prediction and it may suz^est the fresh without hemolysis samples should be used for detection.

关 键 词：化学发光法 产前筛查三联方案 风险预测值 溶血 

分 类 号：R714.52[医药卫生—妇产科学]