孕二烯酮微量杂质分离及其结构测定  

Separation and Structure Elucidation of Minute Impurity in Gestodene Product

作　　者：陈良康[1] 白秀梅[1] 陈建兴[1] 陈海林[1] 

机构地区：[1]上海市计划生育科学研究所,上海200032

出　　处：《中国医药工业杂志》2000年第2期73-75,共3页Chinese Journal of Pharmaceuticals

基　　金：国家科委重点攻关项目! (编号 :K89-0 1-3 1)

摘　　要：采用柱色谱方法分离孕二烯酮(1)中的杂质,经UV、IR、NMR、MS光谱确证其结构为15α-乙酰氧基炔化物(2),并分析其形成过程。The impurity in gestodene product was separated by repeated column chromatography. Its chemical structure was elucidated as 15α acetoxy 17α ethynyl 17β hydroxy 18 methyl 4 estren 3 one on the basis of its UV,IR,NMR,MS data. A possible mechanism for its formation is proposed.

关 键 词：孕二烯酮 杂质 分离 结构测定 

分 类 号：R979.21[医药卫生—药品] R927.12[医药卫生—药学]