Th17/Treg细胞失衡与再生障碍性贫血研究进展  

Recent Progress of Study on Imbalance of Th17/Treg Cells in Aplastic Anemia——Review

作　　者：杨友卫[1] 郑智茵[1] 姚红章[2] 

机构地区：[1]浙江中医药大学附属第一医院血液科,浙江杭州310006 [2]浙江中医药大学附属第一医院血液病研究所,浙江杭州310006

出　　处：《中国实验血液学杂志》2012年第1期214-218,共5页Journal of Experimental Hematology

基　　金：浙江省科技计划项目(编号2010C33098);浙江省中医药科技计划项目(编号2010ZB035)

摘　　要：再生障碍性贫血(aplastic anemia,AA)是一种以效应T细胞功能亢进导致造血组织损伤为特征的自身免疫性疾病。近年来研究发现,AA与Th17细胞数量增加及Treg细胞数量减少密切相关,且Th17和Treg细胞功能上相互拮抗。动物实验表明,IL-17抗体靶向治疗及Treg细胞回输治疗均可改善免疫介导的AA小鼠骨髓衰竭状态。本文就Th17/Treg细胞与AA关系最新研究进展作一综述,旨在进一步探讨AA发病机制,为临床治疗提供新思路。本综述讨论的主要问题有:Th17/Treg细胞一般生物学特性,Th17/Treg细胞平衡的调节及相关细胞因子,Th17/Treg细胞与再生障碍性贫血关系等。Aplastic anemia （AA） is an autoimmune disease characterized by destruction of hematopoietic tissue resulting in hyperfunction of effector T-lymphocytes. Recent studies indicate that Thl7 and Treg cells are functionally antagonistic each other, and the increase of Th17 cells and decrease of Treg cells are closely related with AA. In vivo experiments showed that both anti-IL-17 treatment and Treg cell infusion can protect against immune-mediated bone marrow failure in mouse with AA. This review summarizes the recent progress of study on imbalance of Th17/ Treg cells in AA, so as to explore the pathogenesis of AA and provide approach to clinical treatment. The main problems that are discussed in this review include biological characteristics of Th17/Treg cells, the regulation of Th17/Treg cell balance and related cvtokines, the relationshio between Thl7/Tre~ ceils and AA.

关 键 词：TH17细胞 TREG细胞 再生障碍性贫血 

分 类 号：R556.5[医药卫生—血液循环系统疾病]